Chemical warfare agent countermeasures based on macrocycle supramolecular chemistry

Given that chemical warfare agents (CWAs) pose some of the largest threats to humankind, social stability, and world peace, considerable attention has been drawn to the development of the corresponding detection, decontamination, and treatment techniques. The versatile functionality and distinctive recognition potency of macrocycles enable their customized design for specific tasks, such as chemical sensing, catalysis, or separation. Hence, supramolecular materials are well suited for the establishment of CWA countermeasures. Herein, we summarize the recent progress in the development of macrocycle-based materials for counteracting several representative CWAs, including nerve, blister, blood, incapacitating, choking, and irritating agents, providing a foundation for further advances in this field and fostering practical translational terms.