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Cyano migration-mediated radical-polar crossover cyclopropanation

  • Ziqiang Wang,
  • Yasu Chen,
  • Jie Li,
  • Chen Zhu

摘要

We report a novel cyano migration-mediated radical-polar crossover process, whereby both the sulfonylcyanation of aliphatic alkenes and the formation of cyclopropanes are concurrently achieved. This transformation yields a diverse array of multi-substituted cyclopropanes under mild photocatalytic conditions. Mechanistic studies elucidate that the reaction proceeds via intramolecular nucleophilic substitution, leading to the formation of the cyclopropane derivatives.