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Purpose <p>In this paper, the authors report a hidden administration of mifepristone, an antiprogestogen used in abortion procedure, by the boyfriend of a pregnant woman. After drinking an iced tea, the woman experienced pelvic cramps and then expulsed products of conception. Due to conflicts in the couple, she suspected a surreptitious administration of an abortion medicine and reported the fact to the police.</p> Methods <p>Urine was collected 3&#xa0;days after the event, while a strand of head hair was collected 1&#xa0;month later.</p> <p>Urine and hair samples were tested for mifepristone using a liquid chromatography system coupled to tandem mass spectrometry. The limits of detection and quantification were 0.05 and 0.1&#xa0;ng/mL for urine and 0.5 and 1&#xa0;pg/mg for hair, respectively.</p> Results <p>Urine and the hair segment corresponding to the period of the event were positive for mifepristone at 0.4&#xa0;ng/mL and 1.4&#xa0;pg/mg, respectively.</p> Conclusion <p>The presence of mifepristone in both biological specimens demonstrates that the woman was exposed to the drug at the period of the event. The findings of this case make a valuable contribution to the literature, addressing an important gap regarding the concentrations found in biological matrices. There is a few data available in the literature, and these results help to expand knowledge on the subject.</p>

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Non-consensual administration of mifepristone for hidden abortion: a rare case of drug-facilitated crime

  • 期刊论文

  • 发表日期：

    2025年4月19日

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  • Laurie Gheddar,
  • Audrey Farrugia,
  • Jean-Sébastien Raul,
  • Pascal Kintz

摘要

Purpose

In this paper, the authors report a hidden administration of mifepristone, an antiprogestogen used in abortion procedure, by the boyfriend of a pregnant woman. After drinking an iced tea, the woman experienced pelvic cramps and then expulsed products of conception. Due to conflicts in the couple, she suspected a surreptitious administration of an abortion medicine and reported the fact to the police.

Methods

Urine was collected 3 days after the event, while a strand of head hair was collected 1 month later.

Urine and hair samples were tested for mifepristone using a liquid chromatography system coupled to tandem mass spectrometry. The limits of detection and quantification were 0.05 and 0.1 ng/mL for urine and 0.5 and 1 pg/mg for hair, respectively.

Results

Urine and the hair segment corresponding to the period of the event were positive for mifepristone at 0.4 ng/mL and 1.4 pg/mg, respectively.

Conclusion

The presence of mifepristone in both biological specimens demonstrates that the woman was exposed to the drug at the period of the event. The findings of this case make a valuable contribution to the literature, addressing an important gap regarding the concentrations found in biological matrices. There is a few data available in the literature, and these results help to expand knowledge on the subject.