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<p>Five new compounds Ephedplics E-I were isolated from the roots of <i>Ephedra sinica</i> Stapf, including three lignans (<b>1–3</b>) and two benzofuran-type compounds (<b>4–5</b>). Their structures were elucidated by spectroscopic methods, involving UV, IR, NMR spectra and HRESIMS analyses. The absolute configuration of compounds <b>1–5</b> was determined by comparing their experimental and calculated ECD spectra. All compounds were assessed for their neuroprotective activities against damage induced by corticosterone (CORT) in PC-12 cells. Compounds <b>1</b> and <b>2</b> were capable of significantly ameliorating CORT-induced PC-12 injury.</p> Graphical abstract <p></p>

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Ephedplics E-I: three lignans and two benzofuran-type compounds from the roots of Ephedra sinica Stapf and their neuroprotective activity

  • 期刊论文

  • 发表日期：

    2026年7月17日

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  • Yunlong Dou,
  • Bowen Zhang,
  • Meng Li,
  • Xiaolan Wang,
  • Shuyan Liu,
  • Yanjun Sun,
  • Xiaoke Zheng,
  • Weisheng Feng

摘要

Five new compounds Ephedplics E-I were isolated from the roots of Ephedra sinica Stapf, including three lignans (1–3) and two benzofuran-type compounds (4–5). Their structures were elucidated by spectroscopic methods, involving UV, IR, NMR spectra and HRESIMS analyses. The absolute configuration of compounds 1–5 was determined by comparing their experimental and calculated ECD spectra. All compounds were assessed for their neuroprotective activities against damage induced by corticosterone (CORT) in PC-12 cells. Compounds 1 and 2 were capable of significantly ameliorating CORT-induced PC-12 injury.

Graphical abstract