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<p>A new dimeric indole alkaloid, cyclosebistine A consisting of an aspidosperma type and a modified iboga type through [2 + 2] cycloaddition was isolated from <i>Catharanthus roseus</i>, and the structure including absolute stereochemistry was determined on the basis of the 2D NMR data and CD calculation. Cyclosebistine A showed reasonably potent anti-malarial activity.</p> Graphical abstract <p></p>

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Cyclosebistine A, a unique anti-malarial bisindole alkaloid from Catharanthus roseus

  • 期刊论文

  • 发表日期：

    2025年12月25日

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  • Yusuke Hirasawa,
  • Risa Domon,
  • Haruto Yoshimura,
  • Ruka Imai,
  • Marin Shiraishi,
  • Nahoko Uchiyama,
  • Hajime Honma,
  • Hiroshi Morita

摘要

A new dimeric indole alkaloid, cyclosebistine A consisting of an aspidosperma type and a modified iboga type through [2 + 2] cycloaddition was isolated from Catharanthus roseus, and the structure including absolute stereochemistry was determined on the basis of the 2D NMR data and CD calculation. Cyclosebistine A showed reasonably potent anti-malarial activity.

Graphical abstract