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<p>Five guanacastane-type diterpenoids, including a novel compound, guanacastepene V (<b>1</b>), and four known compounds (<b>2</b>–<b>5</b>) along with a novel diterpenoid moniliforminol C (<b>6</b>), were isolated from a marine-derived fungus, <i>Coprinellus xanthothrix</i>. The structures of the isolated compounds were elucidated using NMR spectroscopy and computational chemistry. In antifungal assays against <i>Candida auris</i>, an emerging fungal pathogen, compounds <b>1</b> and <b>2</b> exhibited inhibitory activity, with minimum inhibitory concentration values of 6.25 and 3.12&#xa0;µg/mL, respectively. This antifungal effect was specific to <i>C. auris</i>, with minimal activity observed against <i>C. albicans</i>. Moreover, compound <b>4</b> exhibited synergistic effects with amphotericin B.</p> Graphical abstract <p></p>

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Guanacastane-type diterpenoids with antifungal activity against Candida auris isolated from a Marine-derived fungus Coprinellus xanthothrix

  • 期刊论文

  • 发表日期：

    2025年11月23日

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  • Kanako Usui,
  • Hitoshi Kamauchi,
  • Yuki Yatsui,
  • Mikuru Kuroda,
  • Yuka Kiba,
  • Masashi Kitamura,
  • Yoshiaki Sugita

摘要

Five guanacastane-type diterpenoids, including a novel compound, guanacastepene V (1), and four known compounds (2–5) along with a novel diterpenoid moniliforminol C (6), were isolated from a marine-derived fungus, Coprinellus xanthothrix. The structures of the isolated compounds were elucidated using NMR spectroscopy and computational chemistry. In antifungal assays against Candida auris, an emerging fungal pathogen, compounds 1 and 2 exhibited inhibitory activity, with minimum inhibitory concentration values of 6.25 and 3.12 µg/mL, respectively. This antifungal effect was specific to C. auris, with minimal activity observed against C. albicans. Moreover, compound 4 exhibited synergistic effects with amphotericin B.

Graphical abstract