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<p>Four triterpenes with the unprecedented pentacyclic skeletons were isolated from <i>Limax maximus</i>, the traditional medicine of the Zhuang ethnic group in Guangxi. Notably, compounds <b>1</b>−<b>4</b> were characterized by rare&#xa0;7/6/5 tricyclic ring moiety linked to 6/5 bicyclic moiety via three carbon chain. The structures of compounds <b>1</b>−<b>4</b> were elucidated by comprehensive spectroscopic analysis. The absolute configurations of compounds <b>1</b>−<b>2</b> were determined by single-crystal X-ray diffraction analysis using Cu Kα radiation. Biogenetically, compound <b>1</b> could be derived from the tetraepoxysqualenes, via cyclisation and hydroxylation reactions. Bioactivity assay results showed that compound <b>4</b> significantly inhibited LPS-induced NO production in RAW 264.7 cells at 25&#xa0;µM with inhibition of NO production by 47%.</p> Graphical Abstract <p></p>

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Unprecedented triterpenes with anti-inflammatory activity from Limax maximus

  • 期刊论文

  • 发表日期：

    2025年8月1日

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  • Ya-feng Wang,
  • Pei-de Tang,
  • Rui-jie He,
  • Zhang-bin Liu,
  • Yong-qiong Wei,
  • Jun Ruan,
  • Bing-yuan Yang,
  • Yong-lin Huang

摘要

Four triterpenes with the unprecedented pentacyclic skeletons were isolated from Limax maximus, the traditional medicine of the Zhuang ethnic group in Guangxi. Notably, compounds 1−4 were characterized by rare 7/6/5 tricyclic ring moiety linked to 6/5 bicyclic moiety via three carbon chain. The structures of compounds 1−4 were elucidated by comprehensive spectroscopic analysis. The absolute configurations of compounds 1−2 were determined by single-crystal X-ray diffraction analysis using Cu Kα radiation. Biogenetically, compound 1 could be derived from the tetraepoxysqualenes, via cyclisation and hydroxylation reactions. Bioactivity assay results showed that compound 4 significantly inhibited LPS-induced NO production in RAW 264.7 cells at 25 µM with inhibition of NO production by 47%.

Graphical Abstract