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<p>Nine previously undescribed drimane sesquiterpenoids, ganoresinosins A–I (<b>1</b>–<b>9</b>), were isolated from cultures of basidiomycete <i>Ganoderma subresinosum</i>. The absolute configuration of ganoresinosin H (<b>8</b>) was determined using the modified Mosher’s method. Ganoresinosin A (<b>1</b>) showed antimalarial activity against <i>Plasmodium falciparum</i> K1 (IC<sub>50</sub> 34&#xa0;μM), whereas ganoresinosin E (<b>5</b>) exhibited antitubercular activity against <i>Mycobacterium tuberculosis</i> H37Ra (MIC 12.5&#xa0;μg/mL).</p> Graphical abstract <p></p>

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Drimane sesquiterpenoids from cultures of basidiomycete Ganoderma subresinosum

  • 期刊论文

  • 发表日期：

    2025年7月7日

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  • Arunrat Yangchum,
  • Malipan Sappan,
  • Wilunda Choowong,
  • Tuksaporn Thummarukcharoen,
  • Thitiya Boonpratuang,
  • Masahiko Isaka,
  • Prapairat Seephonkai

摘要

Nine previously undescribed drimane sesquiterpenoids, ganoresinosins A–I (1–9), were isolated from cultures of basidiomycete Ganoderma subresinosum. The absolute configuration of ganoresinosin H (8) was determined using the modified Mosher’s method. Ganoresinosin A (1) showed antimalarial activity against Plasmodium falciparum K1 (IC50 34 μM), whereas ganoresinosin E (5) exhibited antitubercular activity against Mycobacterium tuberculosis H37Ra (MIC 12.5 μg/mL).

Graphical abstract