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<p>Seven new triterpene saponins (<b>1</b>–<b>7</b>) and two known saponins (<b>8</b>, <b>9</b>) were isolated from MeOH extracts of <i>Stenocereus gummosus</i> (Engelm.) A.C.Gibson &amp; K.E.Horak. The structures of the isolated saponins were elucidated using MS, IR and comprehensive NMR measurements. To develop drugs for treating Alzheimer's disease (AD) based on the amyloid cascade hypothesis, the isolated saponins were evaluated for inhibition of amyloid beta (Aβ) aggregation using the thioflavin-T (Th-T) assay. Among the isolated saponins, weak activity was observed for compounds<b> 1</b>, <b>2</b>, <b>8</b> and <b>9</b> (IC<sub>50</sub> = 39.0, 36.7, 39.5, and 35.7&#xa0;µM, respectively). The aglycons of the isolated saponins, gummosogenin and alamosenogenin, also showed inhibitory activity related to Aβ aggregation (IC<sub>50</sub> = 14.9 and 15.5&#xa0;µM, respectively).</p> Graphical abstract <p></p>

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Amyloid-β aggregation inhibitory activity of triterpene saponins from the cactus Stenocereus gummosus

  • 期刊论文

  • 发表日期：

    2025年5月8日

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  • Tatsumi Matsumoto,
  • Koji Fujihara,
  • Tomomi Inayama,
  • Hiroaki Sasaki,
  • Kaoru Kinoshita

摘要

Seven new triterpene saponins (1–7) and two known saponins (8, 9) were isolated from MeOH extracts of Stenocereus gummosus (Engelm.) A.C.Gibson & K.E.Horak. The structures of the isolated saponins were elucidated using MS, IR and comprehensive NMR measurements. To develop drugs for treating Alzheimer's disease (AD) based on the amyloid cascade hypothesis, the isolated saponins were evaluated for inhibition of amyloid beta (Aβ) aggregation using the thioflavin-T (Th-T) assay. Among the isolated saponins, weak activity was observed for compounds 1, 2, 8 and 9 (IC50 = 39.0, 36.7, 39.5, and 35.7 µM, respectively). The aglycons of the isolated saponins, gummosogenin and alamosenogenin, also showed inhibitory activity related to Aβ aggregation (IC50 = 14.9 and 15.5 µM, respectively).

Graphical abstract