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<p>The genus <i>Salvia</i> is a well-established source of biologically active compounds with beneficial health effects. In this study, we aimed to isolate and structurally characterize novel compounds from <i>Salvia grandifolia</i> and evaluate their cytotoxic activity against human promyelocytic leukemia (HL-60) and cervical cancer (HeLa) cell lines. Three new rearranged abietane-type diterpenes, grandifolins A–C (<b>1</b>–<b>3</b>) and a new abietane diterpene, grandifolin D (<b>4</b>), were isolated from the roots of <i>Salvia grandifolia,</i> along with 12 known compounds (<b>5</b>–<b>16</b>). Their structures were determined by combining extensive <sup>1</sup>H and <sup>13</sup>C spectroscopy, X-ray crystallography, and electronic circular dichroism spectra (ECD). The skeletons of <b>1</b>–<b>3</b> had a rearranged structure with a 6/6/5 ring from an abietane-type diterpene. A plausible biosynthetic pathway for the rearranged skeleton was also proposed. Many of the isolated compounds showed weak cytotoxicity against HeLa or HL-60 cell lines.</p> Graphical abstract <p></p>

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Grandifolins A–D: three 6/6/5 abietane diterpenes and an abietane diterpene from Salvia grandifolia

  • 期刊论文

  • 发表日期：

    2025年3月2日

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  • Hiroshi Kawabe,
  • Teppei Komiyama,
  • Yoshinori Saito,
  • Yasuko Okamoto,
  • Emi Hara,
  • Keiichi Matsuzaki,
  • Motoo Tori,
  • Ryo Hanai,
  • Hiroshi Hirota,
  • Xun Gong,
  • Chiaki Kuroda,
  • Hiroyuki Kagechika,
  • Ayumi Ohsaki

摘要

The genus Salvia is a well-established source of biologically active compounds with beneficial health effects. In this study, we aimed to isolate and structurally characterize novel compounds from Salvia grandifolia and evaluate their cytotoxic activity against human promyelocytic leukemia (HL-60) and cervical cancer (HeLa) cell lines. Three new rearranged abietane-type diterpenes, grandifolins A–C (1–3) and a new abietane diterpene, grandifolin D (4), were isolated from the roots of Salvia grandifolia, along with 12 known compounds (5–16). Their structures were determined by combining extensive 1H and 13C spectroscopy, X-ray crystallography, and electronic circular dichroism spectra (ECD). The skeletons of 1–3 had a rearranged structure with a 6/6/5 ring from an abietane-type diterpene. A plausible biosynthetic pathway for the rearranged skeleton was also proposed. Many of the isolated compounds showed weak cytotoxicity against HeLa or HL-60 cell lines.

Graphical abstract