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<p>A new diterpenoid, carneadiol (<b>1</b>), with an unprecedented tricyclic carbon skeleton, was isolated from the culture extracts of <i>Nocardia carnea</i> IFM 12324. The structure of compound <b>1</b> was elucidated using spectral studies, including various NMR data. The absolute configuration of <b>1</b> was determined using X-ray crystallographic analysis with the crystalline sponge method. The biosynthetic gene of compound <b>1</b> was deduced, and it was observed that the mRNA of the gene involved in terpenoid cyclization increased significantly in the strain producing compound <b>1</b>.</p> Graphical abstract <p></p>

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A new diterpenoid, carneadiol, isolated from Nocardia carnea IFM 12324

  • 期刊论文

  • 发表日期：

    2025年1月28日

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  • Yasumasa Hara,
  • Ayaka Nakamura,
  • Teruhisa Manome,
  • Akiko Takaya,
  • Hiroki Takahashi,
  • Sayaka Ban,
  • Takashi Yaguchi,
  • Masami Ishibashi

摘要

A new diterpenoid, carneadiol (1), with an unprecedented tricyclic carbon skeleton, was isolated from the culture extracts of Nocardia carnea IFM 12324. The structure of compound 1 was elucidated using spectral studies, including various NMR data. The absolute configuration of 1 was determined using X-ray crystallographic analysis with the crystalline sponge method. The biosynthetic gene of compound 1 was deduced, and it was observed that the mRNA of the gene involved in terpenoid cyclization increased significantly in the strain producing compound 1.

Graphical abstract