Vincarostine A, a novel anti-malarial trimeric monoterpenoid indole alkaloid from Catharanthus roseus

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发表日期：

2024年4月2日

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Yusuke Hirasawa,
Yusuke Kakizoe,
Takahiro Tougan,
Nahoko Uchiyama,
Toshihiro Horii,
Hiroshi Morita

摘要

A novel trimeric monoterpenoid indole alkaloid, vincarostine A (1) consisting of an aspidosperma-iboga-aspidosperma type skeleton, was isolated from the whole plant of Catharanthus roseus. The structure including absolute stereochemistry was elucidated on the basis of 2D NMR data and CD spectrum. Vincarostine A (1) showed anti-malarial activity.

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