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<p>Chronic inflammatory bowel diseases, spondyloarthritis and particularly psoriatic arthritis are not isolated organ diseases but manifestations of a&#xa0;shared gut-joint axis. A&#xa0;significant proportion of patients with Crohn’s disease or ulcerative colitis develop musculoskeletal symptoms, such as spondyloarthritis. Conversely, subclinical signs of intestinal inflammation are often present in rheumatic diseases. From a&#xa0;pathophysiological perspective, barrier disorders, dysbiosis and the interleukin (IL)-23/IL-17 axis connect the mucosa and enthesis, forming an inflammatory network. This transition occurs in stages, via prodromal phases involving subclinical enthesitis and arthralgia. This gives gastroenterology a&#xa0;central role in the early detection of systemic inflammation and the interdisciplinary management of the disease.</p>

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Pathophysiologische Konzepte der Transition zu Spondylarthritis und Psoriasisarthritis

  • 期刊论文

  • 发表日期：

    2026年6月24日

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  • Nadia Ninosu,
  • Anke König,
  • Isabel Rzehak,
  • Alica Kubesch-Grün,
  • Andreas Pinter,
  • Irina Blumenstein,
  • Frank Behrens,
  • Michaela Köhm

摘要

Chronic inflammatory bowel diseases, spondyloarthritis and particularly psoriatic arthritis are not isolated organ diseases but manifestations of a shared gut-joint axis. A significant proportion of patients with Crohn’s disease or ulcerative colitis develop musculoskeletal symptoms, such as spondyloarthritis. Conversely, subclinical signs of intestinal inflammation are often present in rheumatic diseases. From a pathophysiological perspective, barrier disorders, dysbiosis and the interleukin (IL)-23/IL-17 axis connect the mucosa and enthesis, forming an inflammatory network. This transition occurs in stages, via prodromal phases involving subclinical enthesitis and arthralgia. This gives gastroenterology a central role in the early detection of systemic inflammation and the interdisciplinary management of the disease.