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<p>Localized gastroenteropancreatic neuroendocrine tumors (GEP-NET) are primarily amenable to endoscopic resection under low-risk conditions and can, therefore, be treated curatively. Especially localized NETs in the stomach, duodenum, and rectum are well suited for primary endoscopic resection. In recent years, the range of resection techniques has expanded from endoscopic mucosal resection (EMR) to the wider availability of endoscopic submucosal dissection (ESD), endoscopic full-thickness resection (eFTR), and, more recently, endoscopic intermuscular dissection (EID). Endosonography-guided local ablation is also an option for pancreatic NETs such as insulinomas or size-progressive nonfunctional NETs, especially where surgical treatment is contraindicated. This article discusses and classifies the possibilities and limitations of endoscopic resection and ablation for these entities based on available literature.</p>

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Möglichkeiten und Grenzen der endoskopischen Therapie bei lokalisierten gastroenteropankreatischen neuroendokrinen Tumoren

  • 期刊论文

  • 发表日期：

    2025年12月1日

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  • U. Denzer,
  • J. Hochberger,
  • A. Wannhoff,
  • M. Anlauf,
  • N. Begum,
  • M. Hocke,
  • J. Albert

摘要

Localized gastroenteropancreatic neuroendocrine tumors (GEP-NET) are primarily amenable to endoscopic resection under low-risk conditions and can, therefore, be treated curatively. Especially localized NETs in the stomach, duodenum, and rectum are well suited for primary endoscopic resection. In recent years, the range of resection techniques has expanded from endoscopic mucosal resection (EMR) to the wider availability of endoscopic submucosal dissection (ESD), endoscopic full-thickness resection (eFTR), and, more recently, endoscopic intermuscular dissection (EID). Endosonography-guided local ablation is also an option for pancreatic NETs such as insulinomas or size-progressive nonfunctional NETs, especially where surgical treatment is contraindicated. This article discusses and classifies the possibilities and limitations of endoscopic resection and ablation for these entities based on available literature.