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<p>Early detection of a&#xa0;hormonal syndrome caused by a&#xa0;neuroendocrine tumor (NET) is crucial for improving patients’ quality of life and disease-specific survival. Approximately one quarter of NETs cause an endocrine syndrome and are referred to as functional. These tumors are characterized by clinical symptoms accompanied by biochemical evidence of inadequately elevated hormone levels; however, the mere detection of specific hormone expression in tumor tissue using immunohistochemistry is not sufficient for diagnosing a&#xa0;functional NET. Due to the tissue-specific localization of neuroendocrine cell subtypes, the frequent serotonin-producing NETs predominantly occur in the ileum, while most other functional NETs occur in the pancreatic-duodenal region.</p>

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Hormonsyndrome bei neuroendokrinen Tumoren

  • 期刊论文

  • 发表日期：

    2025年11月11日

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  • Harald Lahner,
  • Annie Mathew,
  • Johanna Brägelmann,
  • Wolfgang P. Fendler,
  • Frank Weber,
  • Sarah Theurer,
  • Gilbert Rahe,
  • Dagmar Führer

摘要

Early detection of a hormonal syndrome caused by a neuroendocrine tumor (NET) is crucial for improving patients’ quality of life and disease-specific survival. Approximately one quarter of NETs cause an endocrine syndrome and are referred to as functional. These tumors are characterized by clinical symptoms accompanied by biochemical evidence of inadequately elevated hormone levels; however, the mere detection of specific hormone expression in tumor tissue using immunohistochemistry is not sufficient for diagnosing a functional NET. Due to the tissue-specific localization of neuroendocrine cell subtypes, the frequent serotonin-producing NETs predominantly occur in the ileum, while most other functional NETs occur in the pancreatic-duodenal region.