Aktuelle perioperative Therapiekonzepte beim Rektumkarzinom

Treatment strategies for locally advanced rectal cancer have changed considerably. Uniform treatment with neoadjuvant radio(chemo)therapy (RChT), followed by surgery and, if necessary, adjuvant therapy for all stage II and III patients is no longer appropriate. Instead, treatment corridors can be defined for different situations that take into account the risk of local recurrence and distant metastases on the basis of quality-assured magnetic resonance imaging and allow different treatment options. In addition, organ preservation concepts are becoming increasingly important and molecular predictive factors such as microsatellite instability are also becoming more relevant.