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<p>Excessive artificial light at night (ALAN) disrupts circadian rhythms and may accelerate ocular aging; however, personal objective dosimetry data linking evening light exposure to specific age-related eye diseases (AREDs) remain sparse. The objective of the study is to determine whether personal high-intensity light exposure during the evening transition window (20:00–23:30) is associated with the risk of incident age-related macular degeneration (AMD), cataracts, and glaucoma. This prospective cohort study utilized data from the UK Biobank. Participants (<i>n</i> = 82,826) were monitored for 7&#xa0;days via wrist-worn accelerometers equipped with high-resolution light sensors between 2013 and 2015. Individuals with baseline eye diseases were excluded. Average light intensity (lux) during the evening transition period (20:00–23:30) was categorized by percentiles (top 10% threshold ≈1000&#xa0;lx). Incident AMD, cataract, and glaucoma were identified through linked hospital inpatient records and death registries using ICD-9 and ICD-10 codes. Among 82,826 participants, 6058 incident ARED cases occurred during a median follow-up of 7.85&#xa0;years. Evening light exposure exceeding 1000&#xa0;lx (top 10%) was significantly associated with increased hazards of incident AMD (HR, 1.31; 95% CI, 1.06–1.62), cataract (HR, 1.18; 95% CI, 1.08–1.30), and primary open-angle glaucoma (POAG) (HR, 1.47; 95% CI, 1.07–2.03). Significant time–response relationships were observed, with per-hour exposure to &gt; 2250&#xa0;lx further elevating the risk of overall AREDs (HR, 1.10; 95% CI, 1.04–1.16) and POAG (HR, 1.18; 95% CI, 1.04–1.35). High-intensity artificial light in the evening is an independent, modifiable risk factor for major ocular aging pathologies.</p> Graphical Abstract <p></p>

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Association of high-intensity evening light exposure with risk of incident age-related macular degeneration, cataract, and glaucoma: a prospective cohort study of 82,826 participants

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年6月3日

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  • Xiaoqian Wu,
  • Xinyu Zhang,
  • Yujin Jiang,
  • Zhiyi Gu,
  • Chenxin Li,
  • Xinyu Zhu,
  • Yikeng Huang,
  • Bo Li,
  • Mingming Ma,
  • Shuzhi Zhao,
  • Zhi Zheng

摘要

Excessive artificial light at night (ALAN) disrupts circadian rhythms and may accelerate ocular aging; however, personal objective dosimetry data linking evening light exposure to specific age-related eye diseases (AREDs) remain sparse. The objective of the study is to determine whether personal high-intensity light exposure during the evening transition window (20:00–23:30) is associated with the risk of incident age-related macular degeneration (AMD), cataracts, and glaucoma. This prospective cohort study utilized data from the UK Biobank. Participants (n = 82,826) were monitored for 7 days via wrist-worn accelerometers equipped with high-resolution light sensors between 2013 and 2015. Individuals with baseline eye diseases were excluded. Average light intensity (lux) during the evening transition period (20:00–23:30) was categorized by percentiles (top 10% threshold ≈1000 lx). Incident AMD, cataract, and glaucoma were identified through linked hospital inpatient records and death registries using ICD-9 and ICD-10 codes. Among 82,826 participants, 6058 incident ARED cases occurred during a median follow-up of 7.85 years. Evening light exposure exceeding 1000 lx (top 10%) was significantly associated with increased hazards of incident AMD (HR, 1.31; 95% CI, 1.06–1.62), cataract (HR, 1.18; 95% CI, 1.08–1.30), and primary open-angle glaucoma (POAG) (HR, 1.47; 95% CI, 1.07–2.03). Significant time–response relationships were observed, with per-hour exposure to > 2250 lx further elevating the risk of overall AREDs (HR, 1.10; 95% CI, 1.04–1.16) and POAG (HR, 1.18; 95% CI, 1.04–1.35). High-intensity artificial light in the evening is an independent, modifiable risk factor for major ocular aging pathologies.

Graphical Abstract