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<p>Decreased resting cerebral blood flow and cerebrovascular reactivity (CVR) are important age-related factors associated with an increased risk of stroke or dementia. However, these declines may be exaggerated by a sedentary lifestyle or blunted by engaging in more aerobic-based physical activity. The objective of the present project was to explore differences in resting middle cerebral artery velocity (MCAv), CVR, moderate-to-vigorous intensity physical activity (MVPA), light-intensity physical activity, and sedentary time between healthy younger and older adults. Transcranial Doppler assessed resting right MCAv, and repeated breath hold-derived CVR between 15 younger (27 ± 10&#xa0;years, 11 females) and 14 older adults (67 ± 9&#xa0;years, 9 females). Habitual activity was assessed via a thigh-worn activPAL monitor worn 24-h/day for (6.0 ± 0.8&#xa0;days). As expected, younger adults had higher resting MCAv (65 ± 11 versus 40 ± 22&#xa0;cm/s, <i>p</i> = 0.003) and CVR (5.2 ± 3.2 versus 2.0 ± 0.7&#xa0;cm/s/mmHg, <i>p</i> = 0.004). Older adults engaged in less habitual MVPA (202 ± 103 versus 269 ± 81&#xa0;min/week, <i>p</i> = 0.05) and sedentary time (10.2 ± 2.7 versus 12.2 ± 1.8&#xa0;h/day, <i>p</i> = 0.048) but accrued more light physical activity (575 ± 91 versus 402 ± 89&#xa0;min/week, <i>p</i> = 0.015). Despite engaging in more habitual light physical activity and less sedentary time, older adults still exhibited lower MCAv and CVR compared with their younger peers.</p>

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Engagement in more light physical activity and less sedentary time does not protect against age-related declines in cerebrovascular reactivity in healthy older adults

  • 期刊论文

  • 发表日期：

    2025年12月17日

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  • Molly K. Courish,
  • Abigail V. Wickens,
  • Said Mekary,
  • Myles W. O’Brien,
  • Derek S. Kimmerly

摘要

Decreased resting cerebral blood flow and cerebrovascular reactivity (CVR) are important age-related factors associated with an increased risk of stroke or dementia. However, these declines may be exaggerated by a sedentary lifestyle or blunted by engaging in more aerobic-based physical activity. The objective of the present project was to explore differences in resting middle cerebral artery velocity (MCAv), CVR, moderate-to-vigorous intensity physical activity (MVPA), light-intensity physical activity, and sedentary time between healthy younger and older adults. Transcranial Doppler assessed resting right MCAv, and repeated breath hold-derived CVR between 15 younger (27 ± 10 years, 11 females) and 14 older adults (67 ± 9 years, 9 females). Habitual activity was assessed via a thigh-worn activPAL monitor worn 24-h/day for (6.0 ± 0.8 days). As expected, younger adults had higher resting MCAv (65 ± 11 versus 40 ± 22 cm/s, p = 0.003) and CVR (5.2 ± 3.2 versus 2.0 ± 0.7 cm/s/mmHg, p = 0.004). Older adults engaged in less habitual MVPA (202 ± 103 versus 269 ± 81 min/week, p = 0.05) and sedentary time (10.2 ± 2.7 versus 12.2 ± 1.8 h/day, p = 0.048) but accrued more light physical activity (575 ± 91 versus 402 ± 89 min/week, p = 0.015). Despite engaging in more habitual light physical activity and less sedentary time, older adults still exhibited lower MCAv and CVR compared with their younger peers.