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<p>This study aimed to assess whether dietary nitrate supplementation with resistance training (RT) augments gait performance and functional mobility in inactive middle-aged and older adults. We hypothesized that combining nitrate-rich beetroot juice (BRJ) with RT would yield improvements in gait and functional mobility compared to RT with nitrate-depleted beetroot juice placebo (PLA) supplementation. In this 12-week, randomized, double-blind, placebo-controlled pilot trial, 28 healthy, inactive adults (56 ± 7&#xa0;years) were assigned to either a BRJ (~ 12.8&#xa0;mmol nitrate/day) or PLA group while completing a supervised, full-body RT program (2×/week). Pre- and post-intervention assessments included the instrumented stand and walk (iSAW), 6-min walk test (i6MWT), and timed up and go (iTUG) tests. Supplement adherence, training compliance, and volume were equivalent between groups. ANCOVA analyses controlling baseline values revealed significant between-group differences favoring the BRJ group for gait speed (adjusted means: 1.38 vs 1.27&#xa0;m/s, <i>p</i> = .010), stride length (<i>p</i> &lt; .001), and iTUG duration (<i>p</i> &lt; .05). Within-group analyses confirmed that the BRJ group experienced significant improvements in gait speed (<i>p</i> &lt; 0.001) and iTUG duration (<i>p</i> &lt; 0.05), while the PLA group showed no functional changes, indicating that 12&#xa0;weeks of RT alone was insufficient to improve functional mobility in our sample despite equivalent training responses (<i>p</i> &gt; .05). In our middle-aged sample, supplementing dietary nitrate alongside RT led to clinically meaningful improvements in functional mobility during self-selected conditions, exceeding the gains from 12&#xa0;weeks of twice-weekly RT alone. Preliminary descriptive analyses revealed sex-specific group-level differences that might suggest emerging trends. Although no inferential statistics were conducted, the patterns provide potential directions for future research investigating the effects of RT in middle-aged adults.</p> Graphical Abstract <p></p>

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Beyond strength: dietary nitrate augments self-selected functional mobility after resistance training in middle-aged adults

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年12月18日

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  • Brandon M. Peoples,
  • Mason C. McIntosh,
  • Kenneth D. Harrison,
  • Bria R. Smith,
  • Keven G. Santamaria Guzman,
  • Silvia E. Campos-Vargas,
  • Damaris C. Cifuentes,
  • Breanna J. Mueller,
  • Andreas N. Kavazis,
  • Darren T. Beck,
  • Michael D. Roberts,
  • Jaimie A. Roper

摘要

This study aimed to assess whether dietary nitrate supplementation with resistance training (RT) augments gait performance and functional mobility in inactive middle-aged and older adults. We hypothesized that combining nitrate-rich beetroot juice (BRJ) with RT would yield improvements in gait and functional mobility compared to RT with nitrate-depleted beetroot juice placebo (PLA) supplementation. In this 12-week, randomized, double-blind, placebo-controlled pilot trial, 28 healthy, inactive adults (56 ± 7 years) were assigned to either a BRJ (~ 12.8 mmol nitrate/day) or PLA group while completing a supervised, full-body RT program (2×/week). Pre- and post-intervention assessments included the instrumented stand and walk (iSAW), 6-min walk test (i6MWT), and timed up and go (iTUG) tests. Supplement adherence, training compliance, and volume were equivalent between groups. ANCOVA analyses controlling baseline values revealed significant between-group differences favoring the BRJ group for gait speed (adjusted means: 1.38 vs 1.27 m/s, p = .010), stride length (p < .001), and iTUG duration (p < .05). Within-group analyses confirmed that the BRJ group experienced significant improvements in gait speed (p < 0.001) and iTUG duration (p < 0.05), while the PLA group showed no functional changes, indicating that 12 weeks of RT alone was insufficient to improve functional mobility in our sample despite equivalent training responses (p > .05). In our middle-aged sample, supplementing dietary nitrate alongside RT led to clinically meaningful improvements in functional mobility during self-selected conditions, exceeding the gains from 12 weeks of twice-weekly RT alone. Preliminary descriptive analyses revealed sex-specific group-level differences that might suggest emerging trends. Although no inferential statistics were conducted, the patterns provide potential directions for future research investigating the effects of RT in middle-aged adults.

Graphical Abstract