Scholarlink

<p>This study assessed relationships between age, glucose and insulin metabolism, and cognitive performance in vervet monkeys (<i>Chlorocebus aethiops sabaeus</i>) a valuable model for aging research. Executive function, working memory, body mass index (BMI), and glucose and insulin responses during intravenous glucose tolerance tests (IVGTTs) were assessed in 41 middle-aged to older (9.1–29.5&#xa0;years), socially housed, female vervets. Cluster analyses yielded four distinct IVGTT response patterns relevant to type 2 diabetes development: (I) normal insulin response and euglycemia; (II) baseline euglycemia, hyperinsulinemic response, and adequate glucose clearance; (III) baseline euglycemia, impaired insulin response, and impaired glucose clearance; and (IV) baseline hyperglycemia, impaired insulin response, and hyperglycemia throughout the test. Age was associated with baseline glucose (<i>β</i> = 3.615; <i>p</i> &lt; 0.001), glucose area under the curve (AUC) (<i>β</i> = 321.07; <i>p</i> = 0.002), glucose clearance (<i>β</i> =  − 0.145; <i>p</i> &lt; 0.001), and insulin AUC (<i>β</i> =  − 40.603; <i>p</i> = 0.020). There was a main effect of aging over 1.5&#xa0;years on insulin AUC (<i>β</i> =  − 392.026, <i>p</i> = 0.023). Older animals tended to exhibit more rapid increases in fasting glucose over time (<i>β</i> = 0.986; <i>p</i> = 0.051). Higher BMI was associated with greater insulin resistance (HOMA-IR: <i>β</i> = 0.167; <i>p</i> = 0.004), fasting hyperglycemia (<i>β</i> = 1.120; <i>p</i> = 0.010), and impaired glucose regulation (glucose AUC: <i>β</i> = 136.59; <i>p</i> = 0.001). Worsening glycemic control was associated at follow-up with poorer executive function (<i>χ</i><sup>2</sup> = 8.134; <i>p</i> = 0.043) and tended to be associated with poorer working memory (<i>χ</i><sup>2</sup> = 6.363; <i>p</i> = 0.095). Aging vervets undergo a decline in glucose sensitivity, increasing insulin resistance, and impaired glucose handling. Metabolic perturbations characteristic of worsening prediabetes predicted worse cognition; however, future study is needed identify mechanisms underlying these relationships.</p> Graphical abstract <p></p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Age, glucose tolerance, and cognitive performance in female vervet monkeys

  • 期刊论文

  • 发表日期：

    2025年10月15日

查看全文
  • Brett M. Frye,
  • Trinity G. Davis,
  • Haiying Chen,
  • Thomas C. Register,
  • Suzanne Craft,
  • Mark G. Baxter,
  • Carol A. Shively

摘要

This study assessed relationships between age, glucose and insulin metabolism, and cognitive performance in vervet monkeys (Chlorocebus aethiops sabaeus) a valuable model for aging research. Executive function, working memory, body mass index (BMI), and glucose and insulin responses during intravenous glucose tolerance tests (IVGTTs) were assessed in 41 middle-aged to older (9.1–29.5 years), socially housed, female vervets. Cluster analyses yielded four distinct IVGTT response patterns relevant to type 2 diabetes development: (I) normal insulin response and euglycemia; (II) baseline euglycemia, hyperinsulinemic response, and adequate glucose clearance; (III) baseline euglycemia, impaired insulin response, and impaired glucose clearance; and (IV) baseline hyperglycemia, impaired insulin response, and hyperglycemia throughout the test. Age was associated with baseline glucose (β = 3.615; p < 0.001), glucose area under the curve (AUC) (β = 321.07; p = 0.002), glucose clearance (β =  − 0.145; p < 0.001), and insulin AUC (β =  − 40.603; p = 0.020). There was a main effect of aging over 1.5 years on insulin AUC (β =  − 392.026, p = 0.023). Older animals tended to exhibit more rapid increases in fasting glucose over time (β = 0.986; p = 0.051). Higher BMI was associated with greater insulin resistance (HOMA-IR: β = 0.167; p = 0.004), fasting hyperglycemia (β = 1.120; p = 0.010), and impaired glucose regulation (glucose AUC: β = 136.59; p = 0.001). Worsening glycemic control was associated at follow-up with poorer executive function (χ2 = 8.134; p = 0.043) and tended to be associated with poorer working memory (χ2 = 6.363; p = 0.095). Aging vervets undergo a decline in glucose sensitivity, increasing insulin resistance, and impaired glucose handling. Metabolic perturbations characteristic of worsening prediabetes predicted worse cognition; however, future study is needed identify mechanisms underlying these relationships.

Graphical abstract