Scholarlink

<p>While the CAIDE score is an established mid-life risk assessment tool for the longitudinal prediction of dementia, its application as a measure of elevated cognitive risk in late adulthood is unclear. One hundred one healthy individuals (aged &gt; 55) were tested using detailed neuropsychological assessments, as well as structural and functional MRI. Participants were divided into a low-risk group (CAIDE &lt; 7) and a high-risk group (CAIDE &gt; 6). High-risk participants had significantly worse cognitive performance in the Trail-Making Test results (TMT-B: t = -4.03, <i>p</i> = 0.0001), and significantly smaller global brain volumes (e.g., brain segmentation volume: t = 2.898, <i>p</i> = 0.0485) and regional volumes (e.g., accumbens volumes: t<sub>left</sub> = 3.928, <i>p</i> = 0.036, Cohen’s d = 0.828; t<sub>right</sub> = 3.151, p<sub>=</sub> 0.0485, Cohen’s d = 0.656). High-risk participants also showed a trend for reduced functional connectivity in the default mode, salience, and central attention networks. Overall, the CAIDE score might help identify cognitively high-risk individuals in a late adulthood population.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

The CAIDE dementia risk score indicates elevated cognitive risk in late adulthood: a structural and functional neuroimaging study

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年6月26日

查看全文
  • Katalin Farkas,
  • Timea Lazar,
  • Melinda Becske,
  • Janos Andras Zsuffa,
  • Viktoria Rosenfeld,
  • Dalida Borbala Berente,
  • Gergo Bolla,
  • Janos Negyesi,
  • Andras Attila Horvath

摘要

While the CAIDE score is an established mid-life risk assessment tool for the longitudinal prediction of dementia, its application as a measure of elevated cognitive risk in late adulthood is unclear. One hundred one healthy individuals (aged > 55) were tested using detailed neuropsychological assessments, as well as structural and functional MRI. Participants were divided into a low-risk group (CAIDE < 7) and a high-risk group (CAIDE > 6). High-risk participants had significantly worse cognitive performance in the Trail-Making Test results (TMT-B: t = -4.03, p = 0.0001), and significantly smaller global brain volumes (e.g., brain segmentation volume: t = 2.898, p = 0.0485) and regional volumes (e.g., accumbens volumes: tleft = 3.928, p = 0.036, Cohen’s d = 0.828; tright = 3.151, p= 0.0485, Cohen’s d = 0.656). High-risk participants also showed a trend for reduced functional connectivity in the default mode, salience, and central attention networks. Overall, the CAIDE score might help identify cognitively high-risk individuals in a late adulthood population.