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<p>Endocrine-disrupting chemicals (EDCs) are attracting growing interest due to their effects on humans and on ecosystems. Among suspected EDCs, fluoride is a widespread pollutant in aquatic ecosystems, particularly as a result of fluoridation of drinking water. It has also been described to affect fish development. The aim of this study was to determine if chronic fluoride exposure could affect early life stages of rainbow trout (<i>Oncorhynchus mykiss</i>) especially their growth and thyroid hormone system. Trout embryos were exposed from 6 to 40&#xa0;days post-fertilization, to 0, 1.5, 5, 17, 27.5, or 51.5&#xa0;mg/L. Growth was significantly inhibited by the exposure with shorter larvae and delayed resorption of the yolk sac. Fluoride exposure increased axial skeleton malformations, but had no effect on the occurrence of edema or hemorrhage. Genes <i>tshβ</i>, <i>dio1</i>, <i>dio2</i>, <i>dio3</i>, and <i>thrα</i>, coding for proteins involved in the thyroid hormone system, were overexpressed in a dose-dependent manner. While histopathological changes of thyroid follicles were observed in larvae exposed to fluoride, no difference in the levels of thyroid hormones was highlighted. In conclusion, results indicate that fluoride exposure during early life stages of rainbow trout might affect their growth and development and exhibit multisite effects on the thyroid hormone system.</p>

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Fluoride exposure affects development, thyroid-related gene expression, and follicle histology in early life stages of rainbow trout (Oncorhynchus mykiss)

  • 期刊论文

  • 发表日期：

    2026年7月8日

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  • Marine Suchet,
  • Laure Bellec,
  • Pauline Pannetier,
  • Marian Stoll,
  • Christelle Clérandeau,
  • Yann Combes,
  • Flore Daramy,
  • Fabien Pierron,
  • Lisa Baumann,
  • Blandine Davail,
  • Morgane Danion,
  • Thomas Braunbeck,
  • Thierry Morin,
  • Jérôme Cachot

摘要

Endocrine-disrupting chemicals (EDCs) are attracting growing interest due to their effects on humans and on ecosystems. Among suspected EDCs, fluoride is a widespread pollutant in aquatic ecosystems, particularly as a result of fluoridation of drinking water. It has also been described to affect fish development. The aim of this study was to determine if chronic fluoride exposure could affect early life stages of rainbow trout (Oncorhynchus mykiss) especially their growth and thyroid hormone system. Trout embryos were exposed from 6 to 40 days post-fertilization, to 0, 1.5, 5, 17, 27.5, or 51.5 mg/L. Growth was significantly inhibited by the exposure with shorter larvae and delayed resorption of the yolk sac. Fluoride exposure increased axial skeleton malformations, but had no effect on the occurrence of edema or hemorrhage. Genes tshβ, dio1, dio2, dio3, and thrα, coding for proteins involved in the thyroid hormone system, were overexpressed in a dose-dependent manner. While histopathological changes of thyroid follicles were observed in larvae exposed to fluoride, no difference in the levels of thyroid hormones was highlighted. In conclusion, results indicate that fluoride exposure during early life stages of rainbow trout might affect their growth and development and exhibit multisite effects on the thyroid hormone system.