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<p>During the past few decades, the emergence of resistance against various synthetic insecticides among dengue fever vector <i>Aedes aegypti</i> has posed a drastic challenge in many countries including India. One of the most effective ways to reduce the chance of insecticide resistance is the use of bioactive elements for vector control instead of using synthetic insecticides. Modern vector control strategies have a habit of using less polluting and more selective bio-derived products for mosquito control. In context with the aforementioned concepts, the present study analyzed the susceptibility status of 4th instar larvae of <i>Aedes aegypti</i> towards the plant isolates such as Jatamansone, 2,2,4-Trimethyl-1,3-pentanediol diisobutyrate, and 3-Hydroxy-2,2,4-trimethylpentyl isobutyrate isolated from <i>Jasminum brevilobum</i>, <i>Aglaia edulis</i>, and <i>Pogostemon auricularius</i>. This study provides laboratory-based evidence that three selected bioactive compounds (Jatamansone, 2,2,4-Trimethyl-1,3-pentanediol diisobutyrate, and 3-Hydroxy-2,2,4-trimethylpentyl isobutyrate) induced only moderate resistance (RR &lt; 5) in <i>Aedes aegypti</i> fourth instar larvae after ten generations of selection. These findings suggest that these compounds may have lower resistance-selection potential than many synthetic insecticides under laboratory conditions, warranting further investigation as potential components of integrated vector management strategies. However, environmental and regulatory implications cannot be assessed without additional ecotoxicological and field studies.</p>

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Multi-generational exposure of Aedes aegypti to plant-derived compounds unveils laboratory insights into resistance development and environmental considerations for vector management

  • 期刊论文

  • 发表日期：

    2026年6月1日

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  • Ammini Naduvanthar Anoopkumar,
  • Embalil Mathachan Aneesh

摘要

During the past few decades, the emergence of resistance against various synthetic insecticides among dengue fever vector Aedes aegypti has posed a drastic challenge in many countries including India. One of the most effective ways to reduce the chance of insecticide resistance is the use of bioactive elements for vector control instead of using synthetic insecticides. Modern vector control strategies have a habit of using less polluting and more selective bio-derived products for mosquito control. In context with the aforementioned concepts, the present study analyzed the susceptibility status of 4th instar larvae of Aedes aegypti towards the plant isolates such as Jatamansone, 2,2,4-Trimethyl-1,3-pentanediol diisobutyrate, and 3-Hydroxy-2,2,4-trimethylpentyl isobutyrate isolated from Jasminum brevilobum, Aglaia edulis, and Pogostemon auricularius. This study provides laboratory-based evidence that three selected bioactive compounds (Jatamansone, 2,2,4-Trimethyl-1,3-pentanediol diisobutyrate, and 3-Hydroxy-2,2,4-trimethylpentyl isobutyrate) induced only moderate resistance (RR < 5) in Aedes aegypti fourth instar larvae after ten generations of selection. These findings suggest that these compounds may have lower resistance-selection potential than many synthetic insecticides under laboratory conditions, warranting further investigation as potential components of integrated vector management strategies. However, environmental and regulatory implications cannot be assessed without additional ecotoxicological and field studies.