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<p>Succinate dehydrogenase (complex II of the mitochondrial respiratory chain) plays an essential role in cellular respiration in all living organisms. Its inhibition in humans leads to severe pathologies. It is targeted by succinate dehydrogenase inhibitor (SDHI) pesticides that are seeing a global rise in usage within the farming industry. Concerned about the systemic toxic effects, the use and the regulation of SDHI pesticides, the interdisciplinary Holimitox consortium, made up of sixteen French research laboratories, has been working on the subject for four years. This article is a report of the concluding meeting of the consortium, combining research programme synthesis phases and round table discussions. The Holimitox consortium emphasizes the importance of taking an interest in this family of pesticides, which are still little known yet rapidly expanding, using an integrative EcoHealth approach. This is because the challenges of public health, environmental protection, and biodiversity require a detailed understanding of food and agricultural production chains, economic issues, and the regulatory assessment procedures for these pesticides.</p>

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Report of the scientific network Holimitox on succinate dehydrogenase inhibitor (SDHI) pesticides: new insights and challenges with an EcoHealth approach—presentations and round tables from the Holimitox day on November 7, 2024

  • 期刊论文

  • 发表日期：

    2026年5月27日

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  • Jean-Marc Bonmatin,
  • François Chamaraux,
  • Séverine Jean,
  • Emmanuella Abbey,
  • Erwan Bézard,
  • Lucie Bouly,
  • Bénédicte Buffin-Meyer,
  • Marie Buleon,
  • Thomas Castellino,
  • Frédéric Delbac,
  • David Demortain,
  • Colette Denis,
  • Marie Diogon,
  • Gaelle Dormio,
  • Hicham El Alaoui,
  • Olivier Fardel,
  • Judith Favier,
  • Guylène Feuillet,
  • Juliette Gilbert,
  • Aurianne Hagimont,
  • Marie Kerhoas,
  • Augustin Le Naour,
  • Servane Le Page,
  • Marc Le Vée,
  • Anthony Lemarié,
  • Tristan Lemery,
  • Sophie Lorber,
  • Tom Maillet,
  • Claire Mazzocco,
  • Camille Pasquet,
  • Juliette Pompili,
  • Olivier Puel,
  • Julie Sanceau,
  • Joost Schanstra,
  • Mireille Sebbag,
  • Bastien Soutjis,
  • Rebecca Westbrook,
  • Maxime Zimmermann,
  • Laurence Huc

摘要

Succinate dehydrogenase (complex II of the mitochondrial respiratory chain) plays an essential role in cellular respiration in all living organisms. Its inhibition in humans leads to severe pathologies. It is targeted by succinate dehydrogenase inhibitor (SDHI) pesticides that are seeing a global rise in usage within the farming industry. Concerned about the systemic toxic effects, the use and the regulation of SDHI pesticides, the interdisciplinary Holimitox consortium, made up of sixteen French research laboratories, has been working on the subject for four years. This article is a report of the concluding meeting of the consortium, combining research programme synthesis phases and round table discussions. The Holimitox consortium emphasizes the importance of taking an interest in this family of pesticides, which are still little known yet rapidly expanding, using an integrative EcoHealth approach. This is because the challenges of public health, environmental protection, and biodiversity require a detailed understanding of food and agricultural production chains, economic issues, and the regulatory assessment procedures for these pesticides.