Scholarlink

<p>Acrylamide (ACR) is a toxic compound formed during high-temperature food processing and is also present in cigarette smoke. It induces oxidative stress, apoptosis, and tissue damage, including cutaneous injury. Wheat sprout (WSP), a natural antioxidant-rich agricultural product, may provide protective effects against ACR-induced skin toxicity. This study investigated the protective effects of WSP extract against ACR-induced skin damage in a rat model, with a focus on histomorphometric alterations, oxidative stress, and apoptotic regulation. Twenty adult male rats were randomly assigned to four groups (n = 5 per group): control, ACR-treated (50 mg/kg), ACR + WSP-treated (50 mg/kg ACR + 200 mg/kg WSP), and WSP-treated (200 mg/kg). The treatments were administered orally once daily for 21 days. Skin tissues were examined histologically using hematoxylin and eosin and Masson’s trichrome staining. Oxidative stress biomarkers, including malondialdehyde (MDA), total antioxidant capacity (TAC), and superoxide dismutase (SOD), were measured in the serum, whereas apoptotic markers (p53 and BCL-2) were evaluated using immunohistochemistry. ACR exposure significantly reduced dermal thickness, collagen density, and hair follicle and sebaceous gland profiles, while increasing oxidative stress and apoptotic signaling. Co-administration of WSP significantly mitigated these effects by preserving skin architecture, significantly increasing TAC and SOD levels, reducing MDA concentrations, and modulating apoptotic markers. In conclusion, the WSP extract exerts a protective effect against ACR-induced skin toxicity by enhancing antioxidant defenses, inhibiting apoptosis, and preserving dermal structure, highlighting its potential as a sustainable, agriculture-derived protective agent against environmental dermatotoxicants.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Protective effects of wheat sprouts extract against acrylamide-induced skin toxicity: Modulation of oxidative stress, apoptosis, and histomorphometric alterations in rats

  • 期刊论文

  • 发表日期：

    2026年1月27日

查看全文
  • Hamid Reza Moradi,
  • Azadeh Vafaeyan,
  • Zabihollah Khaksar,
  • Fatemeh Alipour

摘要

Acrylamide (ACR) is a toxic compound formed during high-temperature food processing and is also present in cigarette smoke. It induces oxidative stress, apoptosis, and tissue damage, including cutaneous injury. Wheat sprout (WSP), a natural antioxidant-rich agricultural product, may provide protective effects against ACR-induced skin toxicity. This study investigated the protective effects of WSP extract against ACR-induced skin damage in a rat model, with a focus on histomorphometric alterations, oxidative stress, and apoptotic regulation. Twenty adult male rats were randomly assigned to four groups (n = 5 per group): control, ACR-treated (50 mg/kg), ACR + WSP-treated (50 mg/kg ACR + 200 mg/kg WSP), and WSP-treated (200 mg/kg). The treatments were administered orally once daily for 21 days. Skin tissues were examined histologically using hematoxylin and eosin and Masson’s trichrome staining. Oxidative stress biomarkers, including malondialdehyde (MDA), total antioxidant capacity (TAC), and superoxide dismutase (SOD), were measured in the serum, whereas apoptotic markers (p53 and BCL-2) were evaluated using immunohistochemistry. ACR exposure significantly reduced dermal thickness, collagen density, and hair follicle and sebaceous gland profiles, while increasing oxidative stress and apoptotic signaling. Co-administration of WSP significantly mitigated these effects by preserving skin architecture, significantly increasing TAC and SOD levels, reducing MDA concentrations, and modulating apoptotic markers. In conclusion, the WSP extract exerts a protective effect against ACR-induced skin toxicity by enhancing antioxidant defenses, inhibiting apoptosis, and preserving dermal structure, highlighting its potential as a sustainable, agriculture-derived protective agent against environmental dermatotoxicants.