Scholarlink

<p>Asian sand dust (ASD), a type of fine particulate matter originating from arid regions of East Asia, is known to exacerbate respiratory diseases, but its impact on the ocular surface remains poorly understood. Given the increasing prevalence of allergic conjunctivitis in Japan, particularly during the Japanese cedar pollen (JCP) season, we investigated whether ASD exposure aggravates ocular allergic inflammation. Using a mouse model sensitized with JCP, we found that conjunctival instillation of ASD in combination with JCP significantly increased clinical signs such as hyperemia and edema, along with elevated serum IgE levels and enhanced inflammatory cell infiltration compared to JCP alone. Histological analysis revealed epithelial disruption and increased infiltration of CD3-positive T cells and F4/80-positive macrophages in the ASD/JCP group. These findings demonstrate that ASD exacerbates allergic conjunctivitis by amplifying inflammatory responses on the ocular surface. Our study highlights ASD as a potential environmental risk factor for allergic eye diseases and offers novel mechanistic insights into how airborne pollutants interact with allergen-induced ocular inflammation.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Asian dust exacerbates cedar pollen-induced allergic conjunctivitis in mice

  • 期刊论文

  • 发表日期：

    2025年8月1日

查看全文
  • Tatsuya Mimura,
  • Yasuhiro Yoshida,
  • Takamichi Ichinose

摘要

Asian sand dust (ASD), a type of fine particulate matter originating from arid regions of East Asia, is known to exacerbate respiratory diseases, but its impact on the ocular surface remains poorly understood. Given the increasing prevalence of allergic conjunctivitis in Japan, particularly during the Japanese cedar pollen (JCP) season, we investigated whether ASD exposure aggravates ocular allergic inflammation. Using a mouse model sensitized with JCP, we found that conjunctival instillation of ASD in combination with JCP significantly increased clinical signs such as hyperemia and edema, along with elevated serum IgE levels and enhanced inflammatory cell infiltration compared to JCP alone. Histological analysis revealed epithelial disruption and increased infiltration of CD3-positive T cells and F4/80-positive macrophages in the ASD/JCP group. These findings demonstrate that ASD exacerbates allergic conjunctivitis by amplifying inflammatory responses on the ocular surface. Our study highlights ASD as a potential environmental risk factor for allergic eye diseases and offers novel mechanistic insights into how airborne pollutants interact with allergen-induced ocular inflammation.