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<p>This study assessed the effectiveness of a rehabilitation program on health-related quality of life (QoL) in adults with post COVID-19. This randomized controlled trial included 78 participants assigned to an intervention group (IG, <i>n</i> = 38) or control group (CG, <i>n</i> = 40). The IG received a hybrid 12-week intervention including group training, guided conversations, and an online course with training and educational content. The CG received a passive intervention containing online education. The primary outcome was QoL measured by the PROMIS–Preference Score (PROPr). Secondary outcomes included the PROMIS-29 Profile v2.1, cognitive function, functional status, fatigue, post-exertional malaise, dyspnea, and work productivity at six, 12, and 18&#xa0;weeks. After 12&#xa0;weeks, QoL improved significantly in the IG (+ 0.06, <i>p</i> = 0.05) and decreased in the CG (− 0.005, <i>p</i> = 0.83). Ability to participate (+ 3.5, <i>p</i> = 0.015 vs. + 1.51, <i>p</i> = 0.0495) and fatigue (− 0.33, <i>p</i> = 0.035 vs. − 0.33, <i>p</i> = 0.02) improved in both groups. Cognitive function (+ 2.42, p = 0.03) improved in the IG. Sleep disturbance worsened in the CG (+ 3.22, <i>p</i> = 0.01). Between-group differences were significant for physical function (p = 0.036, ε<sup>2</sup> = 0.068), anxiety (<i>p</i> = 0.018, ε<sup>2</sup> = 0.085), and sleep disturbance (p = 0.033, ε<sup>2</sup> = 0.07), with improvements in physical function and sleep disturbance in the IG, while anxiety improved in both. Both groups showed improvements; however, the combination of group training and home-based exercises demonstrated some advantages over online education in QoL, physical function, anxiety, and sleep disturbance. Trial registration: <a href="https://doi.org/10.17605/OSF.IO/2UHTZ">https://doi.org/10.17605/OSF.IO/2UHTZ</a> (May 16, 2023).</p>

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Additional effects of group training and online exercise to a 12-week online pacing and education module on health-related quality of life in adult patients with post COVID-19: a randomized controlled trial

  • 期刊论文

  • 发表日期：

    2026年8月2日

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  • Sophie Gartemann,
  • Kerstin Luedtke

摘要

This study assessed the effectiveness of a rehabilitation program on health-related quality of life (QoL) in adults with post COVID-19. This randomized controlled trial included 78 participants assigned to an intervention group (IG, n = 38) or control group (CG, n = 40). The IG received a hybrid 12-week intervention including group training, guided conversations, and an online course with training and educational content. The CG received a passive intervention containing online education. The primary outcome was QoL measured by the PROMIS–Preference Score (PROPr). Secondary outcomes included the PROMIS-29 Profile v2.1, cognitive function, functional status, fatigue, post-exertional malaise, dyspnea, and work productivity at six, 12, and 18 weeks. After 12 weeks, QoL improved significantly in the IG (+ 0.06, p = 0.05) and decreased in the CG (− 0.005, p = 0.83). Ability to participate (+ 3.5, p = 0.015 vs. + 1.51, p = 0.0495) and fatigue (− 0.33, p = 0.035 vs. − 0.33, p = 0.02) improved in both groups. Cognitive function (+ 2.42, p = 0.03) improved in the IG. Sleep disturbance worsened in the CG (+ 3.22, p = 0.01). Between-group differences were significant for physical function (p = 0.036, ε2 = 0.068), anxiety (p = 0.018, ε2 = 0.085), and sleep disturbance (p = 0.033, ε2 = 0.07), with improvements in physical function and sleep disturbance in the IG, while anxiety improved in both. Both groups showed improvements; however, the combination of group training and home-based exercises demonstrated some advantages over online education in QoL, physical function, anxiety, and sleep disturbance. Trial registration: https://doi.org/10.17605/OSF.IO/2UHTZ (May 16, 2023).