Purpose <p>This randomized controlled trial compared the effects of FIFA 11 + with traditional warm-up programs on professional football players' agility, balance, and proprioception.</p> Methods <p>44 professional football players aged between 18–30 years were randomly assigned into two groups. FIFA 11 + training group (FTG) (<i>n</i> = 22, 27.8 ± 4.7 years) performed the 11 + program for 10 weeks, and the control group (CG) (<i>n</i> = 22, 25.5 ± 4.6 years) did their usual warm-up program. Agility was assessed using the Illinois <i>T</i> test. The Y balance test was used to evaluate dynamic balance. Proprioception was assessed as the ability to reposition the knee at 30, 45, and 60℃ for both the player's right and left leg. Both warm-up protocols were performed before regular football training sessions three times per week for 10 weeks.</p> Results <p>Post-intervention (10th week) scores showed significant differences in all parameters compared to pre-scores in the experimental group (<i>p</i> &lt; 0.05). Moreover, there were significant improvements in Illinois agility and Y balance scores in 11 + groups compared to control groups (<i>P</i> &lt; 0.05).</p> Conclusions <p>The FIFA 11 + program appears to be a more effective warm-up protocol than traditional routines for improving agility, balance, and proprioception. These improvements may contribute to enhanced movement control and reduced injury risk during play.</p> <p>Clinical Trial Registry Name and Registration Number TCil-0096/NCT06472687.</p>