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Purposes <p>Irregular and high-intensity exercise has been demonstrated to exert a detrimental effect on numerous physiological systems. The present study was conducted with the objective of investigating the potential protective roles of a standardized <i>Ginkgo biloba</i> extract (EGb761) against the effects of acute exhaustive exercise (AEE) on plasma reproductive hormones, oxidative stress markers, sperm parameters, and testicular tissue in rats.</p> Methods <p>A total of 30 Wistar albino rats were randomly assigned to four groups: control (C), EGb761 (GB), exercise (E), and EGb761 plus exercise (GB + E). Rats in Groups C and E received physiological saline for a period of 4&#xa0;weeks (five days per week), whereas those in Groups GB and GB + E were administered 100&#xa0;mg/kg body weight of EGb761. On the final day of the experiment, rats in Groups E and GB + E were subjected to running until exhaustion. Subsequently, a comprehensive array of biochemical, spermatological, and histopathological analyses was conducted on blood and testicular tissues obtained from all animals.</p> Results <p>We observed that AEE significantly (<i>p</i> &lt; 0.05) reduced plasma luteinizing hormone (LH) and testosterone levels, as well as mitochondrial membrane potential, while increasing total antioxidant capacity (TAC), total oxidant capacity (TOC), lactate dehydrogenase (LDH) levels, and the testis-to-epididymis weight ratio (<i>p</i> &lt; 0.05). AEE induced marked testicular damage, as evidenced by a significant decrease in Johnsen score and an increase in histopathological scores (<i>p</i> &lt; 0.05). In contrast, <i>EGb761</i> supplementation significantly (<i>p</i> &lt; 0.05) alleviated the majority of these exercise-induced alterations.</p> Conclusion <p>In conclusion, to the best of our knowledge, this is the first study suggesting that EGb761 supplementation may attenuate certain oxidative and reproductive alterations associated with acute exhaustive exercise in rats; however, further mechanistic and translational studies are needed to confirm these findings.</p>

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Ginkgo biloba ameliorated acute exhaustive exercise induced oxidative stress and testicular damage in male rats

  • 期刊论文

  • 发表日期：

    2026年6月15日

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  • Abdulkadir Kaya,
  • Ruhi Kabakçı,
  • Merve Bişkin Türkmen,
  • Taha Altuğ,
  • Hatice Kübra Nur Boran,
  • Yasemin Çınar

摘要

Purposes

Irregular and high-intensity exercise has been demonstrated to exert a detrimental effect on numerous physiological systems. The present study was conducted with the objective of investigating the potential protective roles of a standardized Ginkgo biloba extract (EGb761) against the effects of acute exhaustive exercise (AEE) on plasma reproductive hormones, oxidative stress markers, sperm parameters, and testicular tissue in rats.

Methods

A total of 30 Wistar albino rats were randomly assigned to four groups: control (C), EGb761 (GB), exercise (E), and EGb761 plus exercise (GB + E). Rats in Groups C and E received physiological saline for a period of 4 weeks (five days per week), whereas those in Groups GB and GB + E were administered 100 mg/kg body weight of EGb761. On the final day of the experiment, rats in Groups E and GB + E were subjected to running until exhaustion. Subsequently, a comprehensive array of biochemical, spermatological, and histopathological analyses was conducted on blood and testicular tissues obtained from all animals.

Results

We observed that AEE significantly (p < 0.05) reduced plasma luteinizing hormone (LH) and testosterone levels, as well as mitochondrial membrane potential, while increasing total antioxidant capacity (TAC), total oxidant capacity (TOC), lactate dehydrogenase (LDH) levels, and the testis-to-epididymis weight ratio (p < 0.05). AEE induced marked testicular damage, as evidenced by a significant decrease in Johnsen score and an increase in histopathological scores (p < 0.05). In contrast, EGb761 supplementation significantly (p < 0.05) alleviated the majority of these exercise-induced alterations.

Conclusion

In conclusion, to the best of our knowledge, this is the first study suggesting that EGb761 supplementation may attenuate certain oxidative and reproductive alterations associated with acute exhaustive exercise in rats; however, further mechanistic and translational studies are needed to confirm these findings.