Purpose <p>Falls represent a significant public health concern among aged adults, leading to substantial individual and healthcare system burdens. The aim of this study was to systematically review the literature on the combined effects of exercise program and vitamin D supplementation on the rate of falls and injurious falls in aged adults.</p> Method <p>A comprehensive systematic search was performed in PubMed/Medline, Embase, Scopus, Cochrane Library, Google Scholar and supplemented by manual bibliography searches articles until May 2025. Randomized clinical trials (RCT) with available data about the combined impact of exercise program and vitamin D on the rate of falls and injurious falls in aged 70&#xa0;years and older, based on predefined inclusion and exclusion criteria.</p> Results <p>The search resulted in 1766 publications. Following a thorough review, 29 potentially relevant studies were identified, of which 25 were excluded. Ultimately, three studies were included in this meta-analysis. A total of 570 people (including 38 men and 532 women), aged 70 to 96 years, participated in the study. There was no significant heterogeneity among the studies for the rate of falls (<i>I</i><sup>2</sup> = 0.0009%) and injurious falls (<i>I</i><sup>2</sup> = 0.0003%). Exercise program combined with vitamin D supplementation was not associated with a significant decrease in the rate of falls (<i>RR</i> = 0.88, <i>P</i> = 0.86) and injurious falls (<i>RR</i> = 0.54, <i>P</i> = 0.62) among aged adults in comparison with a control group.</p> Conclusion <p>Current evidence is insufficient to determine whether combining exercise with vitamin D supplementation reduces falls in older adults. Further high-quality trials with larger sample sizes, balanced gender representation, standardized outcome reporting, and stratified analyses based on baseline activity levels and nutritional status are needed to confirm the results of the present study.</p>

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The combined effect of exercise program and oral vitamin D supplementation on the rate of falls and injurious falls in aged 70 years and older: a systematic review and meta-analysis

  • Hadi Pourmanaf,
  • Vahid Sari-Sarraf,
  • Alireza Rashidpour,
  • Morteza Ghojazadeh

摘要

Purpose

Falls represent a significant public health concern among aged adults, leading to substantial individual and healthcare system burdens. The aim of this study was to systematically review the literature on the combined effects of exercise program and vitamin D supplementation on the rate of falls and injurious falls in aged adults.

Method

A comprehensive systematic search was performed in PubMed/Medline, Embase, Scopus, Cochrane Library, Google Scholar and supplemented by manual bibliography searches articles until May 2025. Randomized clinical trials (RCT) with available data about the combined impact of exercise program and vitamin D on the rate of falls and injurious falls in aged 70 years and older, based on predefined inclusion and exclusion criteria.

Results

The search resulted in 1766 publications. Following a thorough review, 29 potentially relevant studies were identified, of which 25 were excluded. Ultimately, three studies were included in this meta-analysis. A total of 570 people (including 38 men and 532 women), aged 70 to 96 years, participated in the study. There was no significant heterogeneity among the studies for the rate of falls (I2 = 0.0009%) and injurious falls (I2 = 0.0003%). Exercise program combined with vitamin D supplementation was not associated with a significant decrease in the rate of falls (RR = 0.88, P = 0.86) and injurious falls (RR = 0.54, P = 0.62) among aged adults in comparison with a control group.

Conclusion

Current evidence is insufficient to determine whether combining exercise with vitamin D supplementation reduces falls in older adults. Further high-quality trials with larger sample sizes, balanced gender representation, standardized outcome reporting, and stratified analyses based on baseline activity levels and nutritional status are needed to confirm the results of the present study.