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Background <p>Resistance training (RT) improves functional fitness and reduces fall risk in older adults. Adherence is crucial for long-term benefits, but its role in maintaining systemic and cellular anti-inflammatory responses over time remains unclear.</p> Purpose <p>This study investigated the impact of long-term RT adherence on systemic and cellular inflammatory responses in trained older women, integrating systemic metabolic/inflammatory profiling with ex-vivo leukocyte stimulation.</p> Methods <p>Seventy-six trained older women (69.5 ± 5.9&#xa0;years) were stratified by lean soft tissue (LST; via DXA) and RT duration (years). Plasma BDNF, MCP-1, and PAI-1 were measured by ELISA. TNF-α, IL-6, and IL-10 release from LPS-stimulated whole blood cultures was also analyzed by ELISA.</p> Results <p>IL-6 concentration inversely correlated with pre-detraining RT duration (rs =  − 0.38, <i>p</i> = 0.007). Women training &gt; 6&#xa0;years exhibited significantly lower stimulated IL-6 (<i>p</i> = 0.001). Reduced IL-6 production was also observed in those with LST &gt; 33.9&#xa0;kg (<i>p</i> = 0.001) and &lt; 42.4&#xa0;kg (<i>p</i> = 0.008) who trained &gt; 6&#xa0;years. This effect persisted after normalization by LST/weight, with women of both higher (LST/Wt &gt; 0.51 and &gt; 0.54; <i>p</i> = 0.003, <i>p</i> = 0.034) and lower relative muscle mass (LST/Wt &lt; 0.59; <i>p</i> = 0.006) showing reduced IL-6 when training &gt; 6&#xa0;years.</p> Conclusion <p>Older women engaging in RT for extended periods (&gt; 6&#xa0;years) with higher LST content demonstrate lower IL-6 concentrations in response to inflammatory stimuli, even following detraining due to COVID-19 restrictions. These findings underscore the importance of sustained RT adherence for modulating inflammatory responses in older women.</p>

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IL-6 production from lipopolysaccharide-stimulated whole blood cells is inversely correlated with duration of resistance training practice in older women: a sub-analysis of the active aging longitudinal study

  • 期刊论文

  • 发表日期：

    2026年1月5日

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  • Tiago Oliveira-Olean,
  • Caique Figueiredo,
  • Barbara Moura Antunes,
  • Edilson S. Cyrino,
  • Fabio Santos Lira,
  • Camila S. Padilha

摘要

Background

Resistance training (RT) improves functional fitness and reduces fall risk in older adults. Adherence is crucial for long-term benefits, but its role in maintaining systemic and cellular anti-inflammatory responses over time remains unclear.

Purpose

This study investigated the impact of long-term RT adherence on systemic and cellular inflammatory responses in trained older women, integrating systemic metabolic/inflammatory profiling with ex-vivo leukocyte stimulation.

Methods

Seventy-six trained older women (69.5 ± 5.9 years) were stratified by lean soft tissue (LST; via DXA) and RT duration (years). Plasma BDNF, MCP-1, and PAI-1 were measured by ELISA. TNF-α, IL-6, and IL-10 release from LPS-stimulated whole blood cultures was also analyzed by ELISA.

Results

IL-6 concentration inversely correlated with pre-detraining RT duration (rs =  − 0.38, p = 0.007). Women training > 6 years exhibited significantly lower stimulated IL-6 (p = 0.001). Reduced IL-6 production was also observed in those with LST > 33.9 kg (p = 0.001) and < 42.4 kg (p = 0.008) who trained > 6 years. This effect persisted after normalization by LST/weight, with women of both higher (LST/Wt > 0.51 and > 0.54; p = 0.003, p = 0.034) and lower relative muscle mass (LST/Wt < 0.59; p = 0.006) showing reduced IL-6 when training > 6 years.

Conclusion

Older women engaging in RT for extended periods (> 6 years) with higher LST content demonstrate lower IL-6 concentrations in response to inflammatory stimuli, even following detraining due to COVID-19 restrictions. These findings underscore the importance of sustained RT adherence for modulating inflammatory responses in older women.