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Background and purpose <p>Traumatic brain injury (TBI) is a common complication in athletes participating in sports competitions. Previous studies have shown that prior exercise can prevent the development of cerebral edema, oxidative stress, and inflammation after TBI. This study investigated the effects of exercise after TBI in male rats with a previous exercise history.</p> Materials and methods <p>Rats were divided into five groups: Sham, only-TBI, Pre-Exercise + Sham, Pre-Exercise + TBI, and Pre-Exercise + TBI + Post-Exercise. The Marmarou’s method created diffuse TBI of moderate intensity. Endurance exercise was performed for 8&#xa0;weeks, 5&#xa0;days a week, with a treadmill before and after TBI. The following exercise was performed 1 week after TBI. At the end of the study of each group, cerebral edema (by determining brain water content), oxidative factors (by measuring malondialdehyde (MDA), carbonyl protein (CP), and total antioxidant activity (TAC)), and inflammatory factors (by measuring interleukin 1β (IL-1β)) of serum were evaluated.</p> Results <p>An increase in brain water content and serum levels of MDA, IL1β, and CP appeared in the only-TBI group compared to the Sham group, while the amount of serum TAC was reduced. The amount of serum MDA decreased in the Pre-Exercise + TBI + Post-Exercise group compared to the only-TBI group. The amount of serum CP and IL-1β, and brain water content in the Pre-Exercise + TBI + Post-Exercise group and Pre-Exercise + TBI group was reduced compared to the only-TBI group.</p> Conclusion <p>In conclusion, TBI increased edema brain, systemic oxidative stress and inflammation, as evidenced by elevated brain water content, serum MDA, protein carbonyl, and IL-1β levels. Combined previous and subsequent exercise in TBI showed partial neuroprotective effects. These findings suggest an effect of endurance exercise on post-TBI pathophysiology in subjects with previous history.</p>

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Does endurance exercise improve cerebral edema, systemic inflammation, and oxidative stress in male rats with previous exercise history after traumatic brain injury?

  • 期刊论文

  • 发表日期：

    2025年9月29日

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  • Farzaneh Rostamzadeh,
  • Zahra Soltani,
  • Mohammad Amin Rajizadeh,
  • Sadegh Amani,
  • Mohammad Shabani,
  • Behshad Mofid

摘要

Background and purpose

Traumatic brain injury (TBI) is a common complication in athletes participating in sports competitions. Previous studies have shown that prior exercise can prevent the development of cerebral edema, oxidative stress, and inflammation after TBI. This study investigated the effects of exercise after TBI in male rats with a previous exercise history.

Materials and methods

Rats were divided into five groups: Sham, only-TBI, Pre-Exercise + Sham, Pre-Exercise + TBI, and Pre-Exercise + TBI + Post-Exercise. The Marmarou’s method created diffuse TBI of moderate intensity. Endurance exercise was performed for 8 weeks, 5 days a week, with a treadmill before and after TBI. The following exercise was performed 1 week after TBI. At the end of the study of each group, cerebral edema (by determining brain water content), oxidative factors (by measuring malondialdehyde (MDA), carbonyl protein (CP), and total antioxidant activity (TAC)), and inflammatory factors (by measuring interleukin 1β (IL-1β)) of serum were evaluated.

Results

An increase in brain water content and serum levels of MDA, IL1β, and CP appeared in the only-TBI group compared to the Sham group, while the amount of serum TAC was reduced. The amount of serum MDA decreased in the Pre-Exercise + TBI + Post-Exercise group compared to the only-TBI group. The amount of serum CP and IL-1β, and brain water content in the Pre-Exercise + TBI + Post-Exercise group and Pre-Exercise + TBI group was reduced compared to the only-TBI group.

Conclusion

In conclusion, TBI increased edema brain, systemic oxidative stress and inflammation, as evidenced by elevated brain water content, serum MDA, protein carbonyl, and IL-1β levels. Combined previous and subsequent exercise in TBI showed partial neuroprotective effects. These findings suggest an effect of endurance exercise on post-TBI pathophysiology in subjects with previous history.