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Background <p>It is well-established that exercise promotes post-exercise hypotension (PEH), a reduction in blood pressure following physical exercise. However, thermogenic substances may induce vasoconstriction, tachycardia, and increased blood pressure, potentially abolishing PEH.</p> Aim <p>To investigate the impact of the use of thermogenic supplements on blood pressure (BP) response and heart rate variability (HRV) after exercise.</p> Methods <p>Twenty healthy normotensive young adults (25 ± 6&#xa0;years), participated in a randomized, placebo-controlled, crossover trial. Each completed two aerobic exercise sessions (60&#xa0;min at 60 − 85% of maximal heart rate), preceded by ingestion of thermogenic supplement (LIPO-6 Black Ultra Concentrated) or placebo (starch), taken 30&#xa0;min before exercise. BP and HRV were measured before supplementation, 30&#xa0;min post-supplementation/pre-exercise (every 10&#xa0;min), and for 60&#xa0;min post-exercise (BP every 15&#xa0;min; HRV every 30&#xa0;min).</p> Results <p>In placebo condition, systolic/diastolic BP decreased at 15 (− 3.3/ − 2.1&#xa0;mmHg), 30 (− 4.2 / 0.8&#xa0;mmHg), 45 (− 6.5/ − 2.1&#xa0;mmHg) and 60 (− 6.3/0.4&#xa0;mmHg) minutes post-exercise. In thermogenic condition, BP increased at 15 (2.6/2.1&#xa0;mmHg), 30 (1.3/2.5&#xa0;mmHg), 45 (1.0/3.4&#xa0;mmHg) and 60 (1.0/5.6&#xa0;mmHg) minutes. ANOVA revealed significant condition × time interactions for systolic (<i>p</i> &lt; 0.01; <i>η</i><sup><i>2</i></sup><sub><i>p</i></sub> = 0.19) and diastolic BP (<i>p</i> &lt; 0.04; <i>η</i><sup><i>2</i></sup><sub><i>p</i></sub> = 0.14). A significant increase in pNN50 was observed in the thermogenic condition (12.9 ± 10&#xa0;ms to 24.8 ± 18&#xa0;ms; <i>p</i> &lt; 0.01) 30&#xa0;min post-supplementation, with no significant change in placebo. RMSSD, LF, and HF remained unchanged.</p> Conclusion <p>Thermogenic supplementation abolished PEH but did not significantly affect HRV in healthy normotensive young adults.</p>

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Thermogenic supplement attenuates post-exercise hypotension after aerobic exercise in normotensive young adults without affecting heart rate variability

  • 期刊论文

  • 发表日期：

    2025年9月12日

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  • Douglas Cavalcante Silva,
  • Reabias de Andrade Pereira,
  • Gustavo da Silva Félix,
  • Marizângela Ferreira de Souza,
  • Glêbia Alexa Cardoso,
  • George Celso Souza Côrtes de Araújo,
  • Marcos Antonio Pereira dos Santos,
  • Alexandre Sérgio Silva

摘要

Background

It is well-established that exercise promotes post-exercise hypotension (PEH), a reduction in blood pressure following physical exercise. However, thermogenic substances may induce vasoconstriction, tachycardia, and increased blood pressure, potentially abolishing PEH.

Aim

To investigate the impact of the use of thermogenic supplements on blood pressure (BP) response and heart rate variability (HRV) after exercise.

Methods

Twenty healthy normotensive young adults (25 ± 6 years), participated in a randomized, placebo-controlled, crossover trial. Each completed two aerobic exercise sessions (60 min at 60 − 85% of maximal heart rate), preceded by ingestion of thermogenic supplement (LIPO-6 Black Ultra Concentrated) or placebo (starch), taken 30 min before exercise. BP and HRV were measured before supplementation, 30 min post-supplementation/pre-exercise (every 10 min), and for 60 min post-exercise (BP every 15 min; HRV every 30 min).

Results

In placebo condition, systolic/diastolic BP decreased at 15 (− 3.3/ − 2.1 mmHg), 30 (− 4.2 / 0.8 mmHg), 45 (− 6.5/ − 2.1 mmHg) and 60 (− 6.3/0.4 mmHg) minutes post-exercise. In thermogenic condition, BP increased at 15 (2.6/2.1 mmHg), 30 (1.3/2.5 mmHg), 45 (1.0/3.4 mmHg) and 60 (1.0/5.6 mmHg) minutes. ANOVA revealed significant condition × time interactions for systolic (p < 0.01; η2p = 0.19) and diastolic BP (p < 0.04; η2p = 0.14). A significant increase in pNN50 was observed in the thermogenic condition (12.9 ± 10 ms to 24.8 ± 18 ms; p < 0.01) 30 min post-supplementation, with no significant change in placebo. RMSSD, LF, and HF remained unchanged.

Conclusion

Thermogenic supplementation abolished PEH but did not significantly affect HRV in healthy normotensive young adults.