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Purpose <p>This study aimed to investigate the time course of β<i>-</i>endorphin (β-EDP) levels in healthy males following an acute exercise, while considering their age and physical fitness (PF) level.</p> Methods <p>Participants (<i>N</i> = 29, 20–65&#xa0;years) were categorized in good PF young adult (YA1), excellent PF young adult (YA2), and excellent PF middle-aged adult (MA) group, depending on peak oxygen uptake and age. They underwent a maximal incremental cycling test, with blood samples collected at baseline (T0), 15&#xa0;min (T1), and 24&#xa0;h post-exercise (T2). Serum β-EDP levels were measured using an ELISA kit.</p> Results <p>Significant increases in β-EDP levels were observed from T0 to T1 in all enrolled subjects. In YA1, levels rose from 170.1 to 202.5&#xa0;pg/ml (<i>p</i> &lt; 0.001), in YA2 from 188.4 to 230.3&#xa0;pg/ml (<i>p</i> &lt; 0.05), and in MA level increased from 153 to 189.3&#xa0;pg/ml (<i>p</i> &lt; 0.01). YA2 showed higher levels of β-EDP than MA in any time point (<i>p</i> &lt; 0.05). All groups displayed a significant decrease of β-EDP from T1 to T2. Comparison between groups revealed that age significantly influenced baseline β-EDP levels, with notable differences between young and middle-aged individuals. Noteworthy, MA with excellent PF presented similar β-EDP levels to young with good PF.</p> Conclusion <p>Acute exercise triggers a notable but transient elevation of serum β-EDP levels in both young and middle-aged adults, with the latter exhibiting lower baseline levels. Additionally, our findings suggest that age may have a greater influence on β-EDP secretion, both at rest and after physical exercise compared to PF level.</p>

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Influence of age and fitness level on β-endorphin response to acute aerobic exercise in healthy men

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年3月9日

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  • Luigi Marano,
  • Ester Tommasini,
  • Sara Missaglia,
  • Paola Vago,
  • Ermanno Rampinini,
  • Andrea Bosio,
  • Andrea Morelli,
  • Claudio Pecci,
  • Alvaro Mordente,
  • Daniela Tavian

摘要

Purpose

This study aimed to investigate the time course of β-endorphin (β-EDP) levels in healthy males following an acute exercise, while considering their age and physical fitness (PF) level.

Methods

Participants (N = 29, 20–65 years) were categorized in good PF young adult (YA1), excellent PF young adult (YA2), and excellent PF middle-aged adult (MA) group, depending on peak oxygen uptake and age. They underwent a maximal incremental cycling test, with blood samples collected at baseline (T0), 15 min (T1), and 24 h post-exercise (T2). Serum β-EDP levels were measured using an ELISA kit.

Results

Significant increases in β-EDP levels were observed from T0 to T1 in all enrolled subjects. In YA1, levels rose from 170.1 to 202.5 pg/ml (p < 0.001), in YA2 from 188.4 to 230.3 pg/ml (p < 0.05), and in MA level increased from 153 to 189.3 pg/ml (p < 0.01). YA2 showed higher levels of β-EDP than MA in any time point (p < 0.05). All groups displayed a significant decrease of β-EDP from T1 to T2. Comparison between groups revealed that age significantly influenced baseline β-EDP levels, with notable differences between young and middle-aged individuals. Noteworthy, MA with excellent PF presented similar β-EDP levels to young with good PF.

Conclusion

Acute exercise triggers a notable but transient elevation of serum β-EDP levels in both young and middle-aged adults, with the latter exhibiting lower baseline levels. Additionally, our findings suggest that age may have a greater influence on β-EDP secretion, both at rest and after physical exercise compared to PF level.