Purpose <p>This study aimed to determine the effect of low-weight resistance exercises performed with blood flow restriction (BFR) on muscle function in patients undergoing post-surgical rehabilitation following anterior cruciate ligament (ACL) reconstruction surgery.</p> Methods <p>Thirty-three patients who had undergone ACL surgery were included in the study. Patients were divided into 3 groups according to the sequential randomization method: low-weight resistance exercise with BFR, low-weight resistance exercise without BFR, and high-weight resistance exercise without BFR. All 3 groups were included in the exercise program for 12 sessions, 3 sessions per week for 4 weeks. As the first test, all participants underwent an isometric strength test on an isokinetic dynamometer device. After the 12th session of the exercise program, isometric strength test and isokinetic strength test were applied to all participants as the post-test.</p> Results <p>There was a significant increase in isometric muscle strength after the exercise protocol in all groups. When the isokinetic test results between the groups were compared; flexion maximum mean torque, flexion peak torque, flexion peak torque/body weight, and mean power parameters were between BFR + low-weight resistance exercise and low-weight resistance exercise groups; A statistically significant difference was found in favor of the BFR + low-weight resistance exercise group (<i>p</i> values 0.022; 0.031; &lt; 0.001; 0.043, respectively).</p> Conclusion <p>Low-weight resistance exercises with BFR present a promising alternative for promoting early muscle strength development in patients recovering from ACL surgery.</p>