Effect of exercise on gait and postural control in patients with chemotherapy induced peripheral neuropathy: a systematic review

Chemotherapy-induced peripheral neuropathy (CIPN) is an adverse effect of frequently used chemotherapy agents in cancer treatment. It is a painful and dose-limiting condition of the peripheral nerves. Exercise is known to limit the progression of CIPN and reduce sensory and motor symptoms. CIPN can be disabling as it leads to loss of balance control, gait disturbances and frequent falls. The study aims to review the effectiveness of different exercise interventions in improving gait speed and postural control in individuals who underwent chemotherapy.

Randomized controlled trials assessing the effect of exercise on postural control and gait are selected. A search strategy was performed in PubMed, PEDro, Scopus, and Web of Science databases. Data were extracted using the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines.

A total of 1450 search results were found, and 4 studies were selected. Exercises like endurance training, balance exercises and sensorimotor training are beneficial in CIPN for reducing postural sway and increasing gait speed. Twice weekly sessions for 30 min each for 4–18 weeks are common exercise regime given to the participants. A combination of more than one type of exercise was shown to be effective in reducing CIPN symptoms.

Exercise is beneficial in improving the postural control and gait parameters in individuals with CIPN. Further studies are required to analyze the potential effect of different exercises to improve gait and balance.