Scholarlink

Purpose <p>Reduced rapid-eye movement (REM) sleep has been linked to increased mortality in the general population. We investigated whether diminished REM sleep is associated with higher mortality in adults with coronary artery disease (CAD) and obstructive sleep apnea (OSA).</p> Methods <p>This secondary analysis of the RICCADSA trial included 356 revascularized CAD patients with OSA (apnea–hypopnea index [AHI] ≥ 15 events/h) and total sleep time (TST) ≥ 240&#xa0;min on baseline polysomnography. Reduced REM sleep was defined as the lowest quartile of REM percentage. Cox proportional hazards models assessed the association between reduced REM sleep and mortality over a median 4.7-year follow-up.</p> Results <p>The lowest REM quartile corresponded to 8.7% of TST. Participants with reduced REM sleep (<i>n</i> = 86) were older (66.0 ± 8.1 vs. 63.0 ± 8.0 years; <i>p</i> = 0.035), had higher BMI (29.8 ± 4.6 vs. 28.7 ± 3.8&#xa0;kg/m²; <i>p</i> = 0.010), shorter TST (369 ± 77 vs. 497 ± 69&#xa0;min; <i>p</i> &lt; 0.001), less slow-wave sleep (5.2 ± 7.0% vs. 8.1 ± 10.0%; <i>p</i> = 0.007), and higher AHI (54.4 ± 26.3 vs. 35.6 ± 20.1 events/h; <i>p</i> &lt; 0.001) than those with REM ≥ 8.7% (<i>n</i> = 270). Mortality was 12.8% in the reduced REM group versus 4.4% in the higher REM group (<i>p</i> = 0.006). Reduced REM sleep independently predicted mortality (hazard ratio 2.39; 95% CI 1.03–5.56; <i>p</i> = 0.043) after adjustment for age, sex, BMI, and CPAP allocation. Further adjustment for TST, slow-wave sleep, baseline AHI, coronary bypass surgery, atrial fibrillation, and REM–AHI interaction did not alter the association.</p> Conclusions <p>Reduced REM sleep independently predicted higher all-cause mortality in revascularized CAD patients with OSA. Identifying diminished REM sleep may help identify particularly vulnerable patients.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Association of reduced REM sleep with mortality in adults with coronary artery disease and obstructive sleep apnea in the RICCADSA cohort

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年2月20日

查看全文
  • Baran Balcan,
  • Yeliz Celik,
  • Erik Thunström,
  • Helena Glantz,
  • Patrick J. Strollo,
  • Susan Redline,
  • Yüksel Peker

摘要

Purpose

Reduced rapid-eye movement (REM) sleep has been linked to increased mortality in the general population. We investigated whether diminished REM sleep is associated with higher mortality in adults with coronary artery disease (CAD) and obstructive sleep apnea (OSA).

Methods

This secondary analysis of the RICCADSA trial included 356 revascularized CAD patients with OSA (apnea–hypopnea index [AHI] ≥ 15 events/h) and total sleep time (TST) ≥ 240 min on baseline polysomnography. Reduced REM sleep was defined as the lowest quartile of REM percentage. Cox proportional hazards models assessed the association between reduced REM sleep and mortality over a median 4.7-year follow-up.

Results

The lowest REM quartile corresponded to 8.7% of TST. Participants with reduced REM sleep (n = 86) were older (66.0 ± 8.1 vs. 63.0 ± 8.0 years; p = 0.035), had higher BMI (29.8 ± 4.6 vs. 28.7 ± 3.8 kg/m²; p = 0.010), shorter TST (369 ± 77 vs. 497 ± 69 min; p < 0.001), less slow-wave sleep (5.2 ± 7.0% vs. 8.1 ± 10.0%; p = 0.007), and higher AHI (54.4 ± 26.3 vs. 35.6 ± 20.1 events/h; p < 0.001) than those with REM ≥ 8.7% (n = 270). Mortality was 12.8% in the reduced REM group versus 4.4% in the higher REM group (p = 0.006). Reduced REM sleep independently predicted mortality (hazard ratio 2.39; 95% CI 1.03–5.56; p = 0.043) after adjustment for age, sex, BMI, and CPAP allocation. Further adjustment for TST, slow-wave sleep, baseline AHI, coronary bypass surgery, atrial fibrillation, and REM–AHI interaction did not alter the association.

Conclusions

Reduced REM sleep independently predicted higher all-cause mortality in revascularized CAD patients with OSA. Identifying diminished REM sleep may help identify particularly vulnerable patients.