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Purpose <p>To evaluate the correlation and relationship between iron parameters including serum iron level, iron-binding capacity, ferritin, transferrin saturation, and the severity of OSAS in the patients who underwent polysomnography.</p> Methods <p>We retrospectively reviewed 209 patients and divided the patients into two groups; AHI ≥ 30 and AHI &lt; 30. The groups were compared using the Mann-Whitney U and the chi-square test. In addition, Spearman’s correlation analysis was performed to analyze the correlation between AHI and iron parameters.</p> Results <p>The mean age of the patients was 47.9 ± 13.7 (19–89) years. Of the 209 patients, 40.7% (<i>n</i> = 85) were female and 59.3% (<i>n</i> = 124) were male. Iron and transferrin saturation was significantly lower in the patients with AHI ≥ 30 compared to the patients with AHI &lt; 30. In female patients, there wasn’t any correlation between AHI and iron, ferritin, transferrin saturation, and iron-binding capacity. But, there was a significant negative correlation between the AHI and iron (<i>r</i> = -0.292, <i>p</i> = 0.001) and transferrin saturation (<i>r</i> = -0.349, <i>p</i> &lt; 0.001) in male patients. Also, the AHI was significantly positively correlated with iron binding capacity (<i>r</i> = 0.307, <i>p</i> = 0.001) in male patients.</p> Conclusion <p>Our results showed that iron levels were lower in severe OSAS. Suggesting that iron levels decrease as a result of oxidative stress and inflammation seen in OSAS, iron parameters may be a good biomarker in OSAS patients.</p>

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Are the serum iron parameters related to the severity of obstructive sleep apnea syndrome?

  • 期刊论文

  • 发表日期：

    2025年3月17日

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  • Merve Yumrukuz Şenel,
  • Rabia Şahin,
  • Mustafa Çolak,
  • Hikmet Çoban,
  • Fuat Erel,
  • Nurhan Sarıoğlu

摘要

Purpose

To evaluate the correlation and relationship between iron parameters including serum iron level, iron-binding capacity, ferritin, transferrin saturation, and the severity of OSAS in the patients who underwent polysomnography.

Methods

We retrospectively reviewed 209 patients and divided the patients into two groups; AHI ≥ 30 and AHI < 30. The groups were compared using the Mann-Whitney U and the chi-square test. In addition, Spearman’s correlation analysis was performed to analyze the correlation between AHI and iron parameters.

Results

The mean age of the patients was 47.9 ± 13.7 (19–89) years. Of the 209 patients, 40.7% (n = 85) were female and 59.3% (n = 124) were male. Iron and transferrin saturation was significantly lower in the patients with AHI ≥ 30 compared to the patients with AHI < 30. In female patients, there wasn’t any correlation between AHI and iron, ferritin, transferrin saturation, and iron-binding capacity. But, there was a significant negative correlation between the AHI and iron (r = -0.292, p = 0.001) and transferrin saturation (r = -0.349, p < 0.001) in male patients. Also, the AHI was significantly positively correlated with iron binding capacity (r = 0.307, p = 0.001) in male patients.

Conclusion

Our results showed that iron levels were lower in severe OSAS. Suggesting that iron levels decrease as a result of oxidative stress and inflammation seen in OSAS, iron parameters may be a good biomarker in OSAS patients.