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Purpose <p>To compare the diagnostic performance of <sup>11</sup>C-acetate and <sup>18</sup>F-FDG across hybrid PET/CT and PET/MRI platforms in patients with multiple myeloma (MM).</p> Methods <p>In this prospective pilot study, seven patients with MM underwent repeated-measures imaging with <sup>18</sup>F-FDG PET/CT, <sup>18</sup>F-FDG PET/MRI, <sup>11</sup>C-acetate PET/CT, and <sup>11</sup>C-acetate PET/MRI. In addition to lesion quantification, the lesions were visually scored for conspicuity. No functional sequences or contrast-enhancement was used in the MRI protocol.</p> Results <p><sup>11</sup>C-acetate detected a greater number of lesions and demonstrated higher visual conspicuity than <sup>18</sup>F-FDG across both PET/CT and PET/MRI platforms.</p> Conclusion <p><sup>11</sup>C-acetate PET imaging may offer improved lesion detection compared to <sup>18</sup>F-FDG in MM. Although the advantage of PET/MRI was not observed over PET/CT in this context, further studies incorporating additional MRI sequences and larger cohorts are warranted.</p>

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Prospective Pilot Study of 11C-acetate and 18F-FDG with PET/CT and PET/MRI for Lesion Detection in Multiple Myeloma

  • 期刊论文

  • 发表日期：

    2026年4月16日

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  • Kristina Yancey,
  • Will Han,
  • Ming Yang,
  • Ba D. Nguyen,
  • Nan Zhang,
  • Kristin Graf,
  • Kevin G. Shim,
  • Erin E. Wiedmeier-Nutor,
  • Udit Yadav,
  • Keith Stewart,
  • Saurabh Chhabra,
  • Leif Bergsagel,
  • Mary Ellen Koran,
  • Felipe Martinez,
  • Steve Huang,
  • Michael Roarke,
  • Rafael Fonseca,
  • Clifford H. Shin

摘要

Purpose

To compare the diagnostic performance of 11C-acetate and 18F-FDG across hybrid PET/CT and PET/MRI platforms in patients with multiple myeloma (MM).

Methods

In this prospective pilot study, seven patients with MM underwent repeated-measures imaging with 18F-FDG PET/CT, 18F-FDG PET/MRI, 11C-acetate PET/CT, and 11C-acetate PET/MRI. In addition to lesion quantification, the lesions were visually scored for conspicuity. No functional sequences or contrast-enhancement was used in the MRI protocol.

Results

11C-acetate detected a greater number of lesions and demonstrated higher visual conspicuity than 18F-FDG across both PET/CT and PET/MRI platforms.

Conclusion

11C-acetate PET imaging may offer improved lesion detection compared to 18F-FDG in MM. Although the advantage of PET/MRI was not observed over PET/CT in this context, further studies incorporating additional MRI sequences and larger cohorts are warranted.