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Purpose <p>To assess alterations in H3R availability with age and body mass index (BMI) in healthy humans using in vivo [<sup>11</sup>C]GSK189254 positron emission tomography (PET) imaging.</p> Procedure <p>Twenty-four healthy individuals (2 females, 22 males; age range 20–47&#xa0;years) were scanned with [<sup>11</sup>C]GSK189254 with High-Resolution Research Tomograph (HRRT) or HR plus scanner. Regional <i>V</i><sub>T</sub> (volume of distribution) values were computed using the two-tissue compartment model. The correlation between <i>V</i><sub>T</sub> and age, BMI were examined, adjusting for relevant potential confounding effects of age or gender and injected mass.</p> Results <p>H3R availability (<i>V</i><sub>T</sub>) was correlated with age but not BMI. <i>V</i><sub>T</sub> displayed a negative correlation with age in the anterior cingulate cortex (r = -0.61, p = 0.004), frontal cortex (r = -0.50, p = 0.020), olfactory cortex (r = -0.50, p = 0.022), parietal cortex (r = -0.58, p = 0.006), cerebellum cortex (r = -0.53, p = 0.013), insula (r = -0.48, p = 0.027), putamen (r = -0.46, p = 0.034), thalamus (r = -0.45, p = 0.038), and hippocampus (r = 0.45, p = 0.039).</p> Conclusion <p>This in vivo H3R study found a significant age-related decline in most cortical and subcortical regions.</p>

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Effects of Age and BMI on Histamine H3 Receptor Availability in Healthy Humans

  • 期刊论文

  • 发表日期：

    2025年9月12日

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  • Yanghong Yang,
  • Waleed Ibrahim,
  • Paul Gravel,
  • Brian Pittman,
  • Jocelyn Hoye,
  • Ryan Cool,
  • Faranak Ebrahimian Sadabad,
  • Ming-Qiang Zheng,
  • Christopher Pittenger,
  • Jean-Dominique Gallezot,
  • Richard E. Carson,
  • Henry Huang,
  • Rajiv Radhakrishnan,
  • David Matuskey

摘要

Purpose

To assess alterations in H3R availability with age and body mass index (BMI) in healthy humans using in vivo [11C]GSK189254 positron emission tomography (PET) imaging.

Procedure

Twenty-four healthy individuals (2 females, 22 males; age range 20–47 years) were scanned with [11C]GSK189254 with High-Resolution Research Tomograph (HRRT) or HR plus scanner. Regional VT (volume of distribution) values were computed using the two-tissue compartment model. The correlation between VT and age, BMI were examined, adjusting for relevant potential confounding effects of age or gender and injected mass.

Results

H3R availability (VT) was correlated with age but not BMI. VT displayed a negative correlation with age in the anterior cingulate cortex (r = -0.61, p = 0.004), frontal cortex (r = -0.50, p = 0.020), olfactory cortex (r = -0.50, p = 0.022), parietal cortex (r = -0.58, p = 0.006), cerebellum cortex (r = -0.53, p = 0.013), insula (r = -0.48, p = 0.027), putamen (r = -0.46, p = 0.034), thalamus (r = -0.45, p = 0.038), and hippocampus (r = 0.45, p = 0.039).

Conclusion

This in vivo H3R study found a significant age-related decline in most cortical and subcortical regions.