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Purpose <p>This study investigated the effects of laterality, age, gender, BMI, and physical activity level on iliac bone turnover using [<sup>18</sup>F]NaF PET/CT.</p> Procedures <p>Fifty-nine males and 44 females from the CAMONA study were analyzed. A region of interest (ROI) was drawn to segment the iliac bone using Hounsfield unit thresholds and morphological closing algorithm. [<sup>18</sup>F]NaF SUVmean was compared between the left and right iliac bones using a paired t-test, while Pearson correlation&#xa0;coefficient assessed changes with age, BMI, and physical activity level.</p> Results <p>[<sup>18</sup>F]NaF uptake was higher in right iliac bone than left in males, females, and the combined-group. In males, SUVmean was 2.98 ± 1.63 (1.1–7.87) on left and 3.71 ± 1.49 (1.49–3.7) on right. In females, SUVmean was 2.59 ± 1.14 (0.88–6.27) on left and 3.72 ± 1.04 (2.22–6.51) on right. Combined, SUVmean was 2.81 ± 1.44 (0.88–7.87) on left and 3.71 ± 1.31 (0.89–8.07) on right. [<sup>18</sup>F]NaF uptake negatively correlated with age (right: r = - 0.27, <i>P</i> = 0.006; left: r = - 0.22, <i>P</i> = 0.02), stronger in females (right: r = - 0.30, <i>P</i> = 0.04; left: r = - 0.31, <i>P</i> = 0.04) than males (right: r = - 0.26, <i>P</i> = 0.04; left: r = - 0.18, <i>P</i> = 0.18). SUVmean correlated positively with BMI in males (right: r = 0.47, <i>P</i> = 0.0002; left: r = 0.38, <i>P</i> = 0.0027), females (right: r = 0.36, <i>P</i> = 0.0168; left: r = 0.30, <i>P</i> = 0.0505),&#xa0;and combined-group (right: r = 0.43, <i>P</i> &lt; 0.0001; left: r = 0.37, <i>P</i> = 0.0001). No significant correlation was found between SUVmean and physical activity in males, while in females, a negative correlation was observed on left (r = - 0.37, <i>P</i> = 0.0390) but not&#xa0;on right (r = - 0.27, <i>P</i> = 0.1302), and when combined, the correlation remained significant on left (r = - 0.24, <i>P</i> = 0.0372) but not on right (r = - 0.16, <i>P</i> = 0.1541).</p> Conclusions <p>[<sup>18</sup>F]NaF uptake was higher in the right iliac bone and declined with age, particularly in females. The positive correlation between SUVmean and BMI; and the negative correlation between SUVmean and physical activity suggest metabolic influences on bone turnover. [<sup>18</sup>F]NaF PET/CT may serve as a tool for assessing bone metabolism and turnover in asymptomatic individuals.</p>

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[18F]NaF PET/CT Imaging of Iliac Bones to Assess Bone Turnover

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年4月24日

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  • Shashi B. Singh,
  • Om H. Gandhi,
  • Bimash B. Shrestha,
  • Patrick Glennan,
  • Anuradha Rosario Bahadur,
  • Niloofaralsadat Motamedi,
  • Kishor Khanal,
  • Sagar Wagle,
  • Poul Flemming Høilund-Carlsen,
  • Thomas J. Werner,
  • Mona-Elisabeth Revheim,
  • Abass Alavi

摘要

Purpose

This study investigated the effects of laterality, age, gender, BMI, and physical activity level on iliac bone turnover using [18F]NaF PET/CT.

Procedures

Fifty-nine males and 44 females from the CAMONA study were analyzed. A region of interest (ROI) was drawn to segment the iliac bone using Hounsfield unit thresholds and morphological closing algorithm. [18F]NaF SUVmean was compared between the left and right iliac bones using a paired t-test, while Pearson correlation coefficient assessed changes with age, BMI, and physical activity level.

Results

[18F]NaF uptake was higher in right iliac bone than left in males, females, and the combined-group. In males, SUVmean was 2.98 ± 1.63 (1.1–7.87) on left and 3.71 ± 1.49 (1.49–3.7) on right. In females, SUVmean was 2.59 ± 1.14 (0.88–6.27) on left and 3.72 ± 1.04 (2.22–6.51) on right. Combined, SUVmean was 2.81 ± 1.44 (0.88–7.87) on left and 3.71 ± 1.31 (0.89–8.07) on right. [18F]NaF uptake negatively correlated with age (right: r = - 0.27, P = 0.006; left: r = - 0.22, P = 0.02), stronger in females (right: r = - 0.30, P = 0.04; left: r = - 0.31, P = 0.04) than males (right: r = - 0.26, P = 0.04; left: r = - 0.18, P = 0.18). SUVmean correlated positively with BMI in males (right: r = 0.47, P = 0.0002; left: r = 0.38, P = 0.0027), females (right: r = 0.36, P = 0.0168; left: r = 0.30, P = 0.0505), and combined-group (right: r = 0.43, P < 0.0001; left: r = 0.37, P = 0.0001). No significant correlation was found between SUVmean and physical activity in males, while in females, a negative correlation was observed on left (r = - 0.37, P = 0.0390) but not on right (r = - 0.27, P = 0.1302), and when combined, the correlation remained significant on left (r = - 0.24, P = 0.0372) but not on right (r = - 0.16, P = 0.1541).

Conclusions

[18F]NaF uptake was higher in the right iliac bone and declined with age, particularly in females. The positive correlation between SUVmean and BMI; and the negative correlation between SUVmean and physical activity suggest metabolic influences on bone turnover. [18F]NaF PET/CT may serve as a tool for assessing bone metabolism and turnover in asymptomatic individuals.