<p>Plants of the Himalayan region produce a wide spectrum of metabolites whose abundance is strongly influenced by species identity, genotype, developmental stage, and environmental factors such as altitude and temperature. These metabolites are of major relevance to the food, cosmetic, and pharmaceutical industries, yet their quality and composition often fluctuate with changing climatic conditions. This review synthesizes available evidence on the influence of environmental gradients particularly altitude and temperature on metabolite production in Himalayan plants, with a special emphasis on seabuckthorn (<i>Hippophae</i> spp.), a species of considerable commercial and pharmacological value. Unlike broader reviews of plant environment interactions, this work focuses specifically on Himalayan taxa, identifies emerging trends across metabolite classes (phenolics, flavonoids, alkaloids, terpenoids, and fatty acids), and highlights the adaptive significance of these compounds under climatic stress. In addition, 16 threatened medicinal plants of the Himalaya are considered, for which information on metabolite responses to environmental variables remains scarce. By integrating findings across species and metabolite groups, this review provides new insights into how Himalayan plants adapt to climatic challenges. Such knowledge is critical for guiding conservation strategies, optimizing cultivation practices, and ensuring the sustainable utilization of these species for nutraceutical and therapeutic applications.</p>