Effect of an acute session of intermittent exercise on trimethylamine N-oxide (TMAO) production following choline ingestion

期刊论文
出版模式：

开放获取
发表日期：

2024年10月5日

查看全文

Marilyn L.Y. Ong,
Christopher G. Green,
Samantha N. Rowland,
Katie Rider,
Harry Sutcliffe,
Mark P. Funnell,
Andrea Salzano,
Liam M. Heaney

摘要

Introduction

Trimethylamine N-oxide (TMAO) is a gut bacteria-dependent metabolite associated with poor cardiovascular health. Exercise is a known cardioprotective activity but the impact of an acute bout of exercise on TMAO production is unknown.

Objectives/Methods

This study assessed choline-derived production of TMAO following a single bout of intermittent exercise in a young, healthy cohort.

Results

Choline supplemented after either exercise or a time-matched resting period demonstrated a similar increase in circulating TMAO across an 8-hour period.

Conclusion

This suggests that a single bout of intermittent exercise does not alter gut microbial metabolic behaviour and thus does not provide additional cardioprotective benefits related to blood levels of TMAO.