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<p>This study investigated the effects of physical exercise (PE) on the modulation of purinergic signaling and inflammatory profiles in sedentary women with type 2 diabetes mellitus (T2DM). Over 16&#xa0;weeks, participants underwent a combined aerobic and resistance training program. The intervention resulted in reduced extracellular ATP levels and decreased activity of E-NTPDase and ADA enzymes, shifting the inflammatory balance toward an anti-inflammatory profile. A significant increase in anti-inflammatory cytokines (IL-10, IL-4) and a decrease in pro-inflammatory markers (TNF-α, IFN-γ, IL-6) were observed in the T2DM group. Correlations indicated that ATP hydrolysis was inversely related to anti-inflammatory cytokines, supporting the role of PE in modulating purinergic pathways. Additionally, improvements in glycemic control, systolic blood pressure, and functional capacity highlighted the systemic benefits of exercise. These findings emphasize the therapeutic potential of PE in managing T2DM by targeting inflammation and metabolic dysregulation through purinergic modulation. Further studies should explore these mechanisms to optimize exercise-based interventions.</p>

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The anti-inflammatory effect of physical exercise on type 2 diabetes: the role of purinergic signaling

  • 期刊论文

  • 发表日期：

    2025年4月16日

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  • Andréia Machado Cardoso,
  • André Campos de Lima,
  • Aline Manica,
  • Daniela Zanini,
  • Lucas Macedo Chaves,
  • Samantha Nuncio Prestes,
  • Sedinei Lopes Copatti,
  • Michele Mainardi Pillat,
  • Taís Vidal,
  • Clodoaldo Antônio de Sá

摘要

This study investigated the effects of physical exercise (PE) on the modulation of purinergic signaling and inflammatory profiles in sedentary women with type 2 diabetes mellitus (T2DM). Over 16 weeks, participants underwent a combined aerobic and resistance training program. The intervention resulted in reduced extracellular ATP levels and decreased activity of E-NTPDase and ADA enzymes, shifting the inflammatory balance toward an anti-inflammatory profile. A significant increase in anti-inflammatory cytokines (IL-10, IL-4) and a decrease in pro-inflammatory markers (TNF-α, IFN-γ, IL-6) were observed in the T2DM group. Correlations indicated that ATP hydrolysis was inversely related to anti-inflammatory cytokines, supporting the role of PE in modulating purinergic pathways. Additionally, improvements in glycemic control, systolic blood pressure, and functional capacity highlighted the systemic benefits of exercise. These findings emphasize the therapeutic potential of PE in managing T2DM by targeting inflammation and metabolic dysregulation through purinergic modulation. Further studies should explore these mechanisms to optimize exercise-based interventions.