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Objective <p>We developed a new phantom for technical evaluation of jawbone single-photon emission computed tomography (SPECT) examinations for medication-related osteonecrosis of the jaw (MRONJ). In this study, we verified the utility of the phantom by determining optimal image reconstruction parameters.</p> Methods <p>We evaluated the image quality and quantification in jawbone SPECT images obtained by different reconstruction parameters using the phantom. The phantom images were acquired using a SPECT/computed tomography (CT) system and then reconstructed using ordered-subset expectation maximization (OSEM) iterative reconstruction with resolution recovery as well as scatter and attenuation correction with various update numbers and Gaussian filter full width at half maximums (FWHMs). The percent contrast (%contrast) and absolute recovery coefficient were calculated to determine the optimal reconstruction parameters (OSEM<sub>jaw</sub>). Nineteen patients with a clinical diagnosis of MRONJ who underwent bone SPECT/CT were enrolled for the clinical study. The performance of OSEM<sub>jaw</sub> was verified by comparison with OSEM<sub>current</sub> determined by a spherical phantom, using the correlation between the mean standardized uptake value (SUV<sub>mean</sub>) and clinical staging and visual assessment as endpoints.</p> Results <p>In the phantom study, %contrast and absolute recovery coefficient increased with increasing update numbers. As the Gaussian filter FWHM increased, the quantitative accuracy and image sharpness decreased. The parameter determined by the phantom study (OSEM<sub>jaw</sub>) recommended 120 updates and no filter.</p> <p>In the clinical study, the mean and standard deviation of SUV<sub>mean</sub> obtained from OSEM<sub>jaw</sub> were 8.9 ± 1.4 for stage 1 lesions, 12.9 ± 4.1 for stage 2 lesions, and 13.8 ± 1.4 for stage 3 lesions. For OSEM<sub>current</sub>, they were 5.4 ± 2.3 for stage 1 lesions, 8.3 ± 2.5 for stage 2 lesions, and 8.0 ± 0.9 for stage 3 lesions. The SUV<sub>mean</sub> obtained from OSEM<sub>jaw</sub> had a stronger correlation with clinical stage. Based on visual assessment, the quality of the SPECT images reconstructed by OSEM<sub>jaw</sub> (3.7 ± 0.9) was superior to that reconstructed by OSEM<sub>current</sub> (2.9 ± 1.1).</p> Conclusions <p>We developed a novel phantom and adapted it for technical evaluation. This study demonstrated the utility of the developed phantom.</p>

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Development of a novel phantom for evaluating jawbone SPECT targeting medication-related osteonecrosis of the jaw

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年2月27日

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  • Naoya Hayashi,
  • Norikazu Matsutomo,
  • Ryotaro Tokorodani,
  • Mitsuha Fukami,
  • Miki Nishimori,
  • Hitomi Iwasa,
  • Kie Nakatani,
  • Tetsuya Yamamoto,
  • Takuji Yamagami,
  • Tomoaki Yamamoto

摘要

Objective

We developed a new phantom for technical evaluation of jawbone single-photon emission computed tomography (SPECT) examinations for medication-related osteonecrosis of the jaw (MRONJ). In this study, we verified the utility of the phantom by determining optimal image reconstruction parameters.

Methods

We evaluated the image quality and quantification in jawbone SPECT images obtained by different reconstruction parameters using the phantom. The phantom images were acquired using a SPECT/computed tomography (CT) system and then reconstructed using ordered-subset expectation maximization (OSEM) iterative reconstruction with resolution recovery as well as scatter and attenuation correction with various update numbers and Gaussian filter full width at half maximums (FWHMs). The percent contrast (%contrast) and absolute recovery coefficient were calculated to determine the optimal reconstruction parameters (OSEMjaw). Nineteen patients with a clinical diagnosis of MRONJ who underwent bone SPECT/CT were enrolled for the clinical study. The performance of OSEMjaw was verified by comparison with OSEMcurrent determined by a spherical phantom, using the correlation between the mean standardized uptake value (SUVmean) and clinical staging and visual assessment as endpoints.

Results

In the phantom study, %contrast and absolute recovery coefficient increased with increasing update numbers. As the Gaussian filter FWHM increased, the quantitative accuracy and image sharpness decreased. The parameter determined by the phantom study (OSEMjaw) recommended 120 updates and no filter.

In the clinical study, the mean and standard deviation of SUVmean obtained from OSEMjaw were 8.9 ± 1.4 for stage 1 lesions, 12.9 ± 4.1 for stage 2 lesions, and 13.8 ± 1.4 for stage 3 lesions. For OSEMcurrent, they were 5.4 ± 2.3 for stage 1 lesions, 8.3 ± 2.5 for stage 2 lesions, and 8.0 ± 0.9 for stage 3 lesions. The SUVmean obtained from OSEMjaw had a stronger correlation with clinical stage. Based on visual assessment, the quality of the SPECT images reconstructed by OSEMjaw (3.7 ± 0.9) was superior to that reconstructed by OSEMcurrent (2.9 ± 1.1).

Conclusions

We developed a novel phantom and adapted it for technical evaluation. This study demonstrated the utility of the developed phantom.