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<p>Aflatoxin is a mycotoxin that contaminates many grain feed ingredients, especially corn. <i>Pichia kudriavzevii</i> B-5P is a yeast strain with potential application in the mitigation of <i>Aspergillus flavus</i> and its associated aflatoxins. This research aims to optimize the dose of <i>Pichia kudriavzevii</i> B-5P as a toxin binder in corn containing aflatoxin in broiler chicken rations along with in vivo evaluation of its protection efficiency on performance, carcass characteristics, serum biochemistry and histopatholical alteration in the liver, kidneys and intestines. This research used a Completely Randomized Design (CRD), 4 treatments and 5 replications. Treatment consisted of T1: control (no aflatoxin); T2: 0,1% <i>P. kudriavzevii</i> B-5P; T3: 0,2% <i>P. kudriavzevii</i> B-5P; T4: 0,3% <i>P. kudriavzevii</i> B-5P. Performance (consumption, weight gain, feed conversion, live weight, and carcass), abdominal fat, percentage of organ weight (liver, kidney, and small intestine), and total protein, albumin, and globulin were not significantly different (<i>p</i> &gt; 0.05) between the control group (without aflatoxin) and the group of chickens fed aflatoxin (191.95 ppb) + <i>Pichia kudriavzevii</i> B-5P. Histopathologically, the liver, kidneys, and small intestine showed mild damage that tended to improve with the administration of <i>P. kudriavzevii</i> B-5P, thereby not affecting organ function. The results of the study concluded that giving <i>Pichia kudriavzevii</i> B-5P as much as 0.1% in feed can overcome aflatoxin contamination with a level of 191.95 ppb in broiler chickens.</p>

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Control of aflatoxin in broiler feeds through dietary supplementation with Pichia kudriavzevii B-5P: effects on performance, serum biochemistry and histopathological change – a promosing strategy

  • 期刊论文

  • 发表日期：

    2025年6月11日

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  • Lili Anggraini,
  • Yetti Marlida,
  • Harnentis,
  • Yuliaty Shafan Nur,
  • Laily Rinda Ardani

摘要

Aflatoxin is a mycotoxin that contaminates many grain feed ingredients, especially corn. Pichia kudriavzevii B-5P is a yeast strain with potential application in the mitigation of Aspergillus flavus and its associated aflatoxins. This research aims to optimize the dose of Pichia kudriavzevii B-5P as a toxin binder in corn containing aflatoxin in broiler chicken rations along with in vivo evaluation of its protection efficiency on performance, carcass characteristics, serum biochemistry and histopatholical alteration in the liver, kidneys and intestines. This research used a Completely Randomized Design (CRD), 4 treatments and 5 replications. Treatment consisted of T1: control (no aflatoxin); T2: 0,1% P. kudriavzevii B-5P; T3: 0,2% P. kudriavzevii B-5P; T4: 0,3% P. kudriavzevii B-5P. Performance (consumption, weight gain, feed conversion, live weight, and carcass), abdominal fat, percentage of organ weight (liver, kidney, and small intestine), and total protein, albumin, and globulin were not significantly different (p > 0.05) between the control group (without aflatoxin) and the group of chickens fed aflatoxin (191.95 ppb) + Pichia kudriavzevii B-5P. Histopathologically, the liver, kidneys, and small intestine showed mild damage that tended to improve with the administration of P. kudriavzevii B-5P, thereby not affecting organ function. The results of the study concluded that giving Pichia kudriavzevii B-5P as much as 0.1% in feed can overcome aflatoxin contamination with a level of 191.95 ppb in broiler chickens.