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<p>Biodegradability is a key parameter in the environmental assessment of chemical substances, requiring robust and reproducible methods to predict their fate. Among strategies aiming to improve the repeatability of biodegradation tests, the design of an artificial inoculum offers several advantages, such as ease of supply, control over its performance, and improved reproducibility. In this study, a panel of 44 microorganisms representative of activated sludge from domestic wastewater treatment plants and available from various strain collections was collected to: (1) evaluate its ability to assess the biodegradability of chemical substances, and (2) classify them into three categories: readily biodegradable, intrinsically biodegradable, and non-biodegradable to persistent. Each strain was individually tested against 30 chemicals with known biodegradability profiles (12 readily biodegradable, 10 inherently biodegradable, 8 non-biodegradable), yielding 3,960 independent 28-day oxygen consumption assays. Strain-level activity was used to derive a classification tool. This approach correctly identified 75% of the readily biodegradable substances reported in the literature. For instance, hexanediol, glycerol, and sodium benzoate induced respiration in 82%, 78%, and 61% of strains, respectively. Intrinsically and non-biodegradable compounds were generally assigned to their expected categories, with some overlap. Certain molecules, such as dimethyl sulfoxide and cyclododecane, showed no measurable respiration. Overall, the artificial inoculum demonstrated strong predictive performance and reproducibility, providing a scalable and high-throughput tool for internal pre-screening of biodegradability and environmental fate assessment.</p>

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Pre-Screening Biodegradability Potential of Chemicals Using an Artificial Bacterial Inoculum

  • 期刊论文

  • 发表日期：

    2026年6月30日

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  • Mickaël Cregut,
  • Cyril Sweetlove,
  • Marie-José Durand,
  • Jean-Charles Chenèble,
  • Armelle Tazé,
  • Odile Dufour,
  • Guillaume Cottin,
  • Marc Léonard,
  • Jacques L’Haridon,
  • Gérald Thouand

摘要

Biodegradability is a key parameter in the environmental assessment of chemical substances, requiring robust and reproducible methods to predict their fate. Among strategies aiming to improve the repeatability of biodegradation tests, the design of an artificial inoculum offers several advantages, such as ease of supply, control over its performance, and improved reproducibility. In this study, a panel of 44 microorganisms representative of activated sludge from domestic wastewater treatment plants and available from various strain collections was collected to: (1) evaluate its ability to assess the biodegradability of chemical substances, and (2) classify them into three categories: readily biodegradable, intrinsically biodegradable, and non-biodegradable to persistent. Each strain was individually tested against 30 chemicals with known biodegradability profiles (12 readily biodegradable, 10 inherently biodegradable, 8 non-biodegradable), yielding 3,960 independent 28-day oxygen consumption assays. Strain-level activity was used to derive a classification tool. This approach correctly identified 75% of the readily biodegradable substances reported in the literature. For instance, hexanediol, glycerol, and sodium benzoate induced respiration in 82%, 78%, and 61% of strains, respectively. Intrinsically and non-biodegradable compounds were generally assigned to their expected categories, with some overlap. Certain molecules, such as dimethyl sulfoxide and cyclododecane, showed no measurable respiration. Overall, the artificial inoculum demonstrated strong predictive performance and reproducibility, providing a scalable and high-throughput tool for internal pre-screening of biodegradability and environmental fate assessment.