Scholarlink

<p>Meloxicam, a widely used non-steroidal anti-inflammatory drug (NSAID), is frequently detected as a persistent pharmaceutical pollutant in hospital and municipal wastewater. Its presence poses significant ecological and public health risks due to its potential for cytotoxicity and mutagenicity. Advanced oxidation processes (AOPs) have gained attention for their effectiveness in degrading such recalcitrant organic contaminants. This study presents a comparative evaluation of two AOPs—UV/Perovskite/H₂O₂ and Gamma/H₂O₂—for the degradation of Meloxicam, a widely detected pharmaceutical pollutant, and the reduction of its cytotoxicity. The UV/Perovskite/H₂O₂ system achieved 82.04% degradation of Meloxicam at 50 ppm, while the UV/H₂O₂ system showed 68.87% degradation at the same concentration. However, the Gamma/H₂O₂ treatment significantly outperformed, achieving complete degradation at 50 ppm owing to the high penetration capability of gamma radiation and the enhanced generation of ROS in the presence of H₂O₂. Toxicity evaluations using hemolysis and Ames tests revealed that Gamma/H₂O₂ reduced red blood cell (RBC) lysis and mutagenicity by more than 90%, substantially higher than those of UV-based treatments. The UV/Perovskite/H₂O₂ system showed a reduction of 87.92% in RBC lysis and 72.31% in mutagenicity, while UV/H₂O₂ resulted in 62.26% and 56.68%, respectively. These findings demonstrate that Gamma/H₂O₂ is the most efficient method for both Meloxicam degradation and toxicity reduction, offering a superior and scalable solution for pharmaceutical removal from wastewater. The comparative analysis underscores the greater effectiveness of Gamma/H₂O₂ in addressing pharmaceutical contamination and ensuring environmental safety.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Synergistic Degradation and Cytotoxicity Mitigation of Meloxicam Using UV/Perovskite/H₂O₂ and Gamma/H₂O₂: A Comparative Study

  • 期刊论文

  • 发表日期：

    2026年2月19日

查看全文
  • Muhammad Asad Khan,
  • Mohamed A. Habib,
  • Muhammad Imran Kanjal,
  • Majid Muneer,
  • Muhammad Asghar Jamal,
  • Tanveer Hussain Bokhari,
  • Usman Irshad,
  • Ahmed B. M. Ibrahim

摘要

Meloxicam, a widely used non-steroidal anti-inflammatory drug (NSAID), is frequently detected as a persistent pharmaceutical pollutant in hospital and municipal wastewater. Its presence poses significant ecological and public health risks due to its potential for cytotoxicity and mutagenicity. Advanced oxidation processes (AOPs) have gained attention for their effectiveness in degrading such recalcitrant organic contaminants. This study presents a comparative evaluation of two AOPs—UV/Perovskite/H₂O₂ and Gamma/H₂O₂—for the degradation of Meloxicam, a widely detected pharmaceutical pollutant, and the reduction of its cytotoxicity. The UV/Perovskite/H₂O₂ system achieved 82.04% degradation of Meloxicam at 50 ppm, while the UV/H₂O₂ system showed 68.87% degradation at the same concentration. However, the Gamma/H₂O₂ treatment significantly outperformed, achieving complete degradation at 50 ppm owing to the high penetration capability of gamma radiation and the enhanced generation of ROS in the presence of H₂O₂. Toxicity evaluations using hemolysis and Ames tests revealed that Gamma/H₂O₂ reduced red blood cell (RBC) lysis and mutagenicity by more than 90%, substantially higher than those of UV-based treatments. The UV/Perovskite/H₂O₂ system showed a reduction of 87.92% in RBC lysis and 72.31% in mutagenicity, while UV/H₂O₂ resulted in 62.26% and 56.68%, respectively. These findings demonstrate that Gamma/H₂O₂ is the most efficient method for both Meloxicam degradation and toxicity reduction, offering a superior and scalable solution for pharmaceutical removal from wastewater. The comparative analysis underscores the greater effectiveness of Gamma/H₂O₂ in addressing pharmaceutical contamination and ensuring environmental safety.