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<p>Nanotechnology is an emerging field with potential benefits in the environment, medicine, and industry. Among the various nanomaterials, titanium dioxide (TiO₂) nanoparticles are particularly notable for their photocatalytic activity, as well as their biocompatibility and chemical stability. This research aimed to synthesize TiO₂ nanoparticles using green synthesis methods through the use of <i>Pittosporum tobira</i> leaf extracts, where the phytochemicals from the plant served as natural reducing and stabilizing agents for the synthesis. The synthesis was verified through UV–visible spectroscopy, which showed a peak at 375&#xa0;nm. FTIR analysis revealed the presence of hydroxyl, aromatic, and Ti–O functional groups, confirming the expected structure. SEM images indicated a nanoparticle size of around 30–40&#xa0;nm, while EDX confirmed that Ti and O were present as primary elements, indicating successful synthesis. The biological evaluation revealed strong activity, with DPPH inhibition reaching 92.5%, anti-inflammatory activity showing 86.9% inhibition of protein denaturation, and anti-hemolytic activity achieving 91.4% inhibition. In addition, green-synthesized TiO₂ nanoparticles degraded PCBs by 91% within five days at a nanoparticle-to-PCB ratio of 1:1. This study presents the first report of TiO₂ nanoparticles synthesized using <i>P. tobira</i> extract, highlighting the novelty and unique potential of this plant in nanoparticle fabrication. Overall, the findings demonstrate that <i>P. tobira</i>-mediated TiO₂ nanoparticles are sustainable, highly active, and multifunctional nanomaterials with significant promise for both environmental detoxification and biomedical applications.</p> Graphical Abstract <p></p>

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Biosynthesis and Biological Assessment of TiO₂ Nanoparticles from Pittosporum Tobira for Antioxidant, Anti-Inflammatory, Anti-Hemolytic Potential, and Polychlorinated Biphenyls Degradation

  • 期刊论文

  • 发表日期：

    2026年1月2日

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  • Muhammad Naveed,
  • Muhammad Asim,
  • Tariq Aziz,
  • Saman Nasir,
  • Maida Salah Ud Din,
  • Nawal Al-Hoshani,
  • Maher S. Alwethaynani,
  • Maymounah A. Alrayyani,
  • Fakhria A. Al-Joufi

摘要

Nanotechnology is an emerging field with potential benefits in the environment, medicine, and industry. Among the various nanomaterials, titanium dioxide (TiO₂) nanoparticles are particularly notable for their photocatalytic activity, as well as their biocompatibility and chemical stability. This research aimed to synthesize TiO₂ nanoparticles using green synthesis methods through the use of Pittosporum tobira leaf extracts, where the phytochemicals from the plant served as natural reducing and stabilizing agents for the synthesis. The synthesis was verified through UV–visible spectroscopy, which showed a peak at 375 nm. FTIR analysis revealed the presence of hydroxyl, aromatic, and Ti–O functional groups, confirming the expected structure. SEM images indicated a nanoparticle size of around 30–40 nm, while EDX confirmed that Ti and O were present as primary elements, indicating successful synthesis. The biological evaluation revealed strong activity, with DPPH inhibition reaching 92.5%, anti-inflammatory activity showing 86.9% inhibition of protein denaturation, and anti-hemolytic activity achieving 91.4% inhibition. In addition, green-synthesized TiO₂ nanoparticles degraded PCBs by 91% within five days at a nanoparticle-to-PCB ratio of 1:1. This study presents the first report of TiO₂ nanoparticles synthesized using P. tobira extract, highlighting the novelty and unique potential of this plant in nanoparticle fabrication. Overall, the findings demonstrate that P. tobira-mediated TiO₂ nanoparticles are sustainable, highly active, and multifunctional nanomaterials with significant promise for both environmental detoxification and biomedical applications.

Graphical Abstract