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<p><i>Orthoreovirus mammalis</i> (MRV) can infect a wide range of mammals, including humans and bats, and the cross-species transmission of the virus poses a potential threat to the health of humans and other animals. In this study, we identified a novel MRV strain from diarrheic pigs in Hunan Province, China. Genetic analysis revealed that the virus is a reassortant, containing segments derived from human, porcine, and mink MRVs. Designated as MRV3-HNU-XXS-2020, the strain clusters within Lineage IV of MRV3 and shows the highest nucleotide identity (98.79%) and amino acid identity (98.02%) to the MRV3 strain IND/MZ/3013789/reo derived from Indian pigs in 2017. The σ1 protein of the virus contains the amino acid residues linked to the sialic acid-binding site as well as neurotropism (198–204 NLAIRLP, 249I, 340D, 419E), suggesting a potential for broader mammalian infectivity. This study provides a basis for investigating the epidemiology, genetic evolution, and zoonotic spillover potential of MRV in mammals.</p>

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Isolation and characterization of a novel reassortant strain of Orthoreovirus mammalis from diarrheic pig

  • 期刊论文

  • 发表日期：

    2025年10月21日

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  • Jing-Ying Liao,
  • Jia-Yao Hou,
  • Yin Shi,
  • Hui Tang,
  • Yi-Shuai Zhang,
  • Chao-Ting Xiao

摘要

Orthoreovirus mammalis (MRV) can infect a wide range of mammals, including humans and bats, and the cross-species transmission of the virus poses a potential threat to the health of humans and other animals. In this study, we identified a novel MRV strain from diarrheic pigs in Hunan Province, China. Genetic analysis revealed that the virus is a reassortant, containing segments derived from human, porcine, and mink MRVs. Designated as MRV3-HNU-XXS-2020, the strain clusters within Lineage IV of MRV3 and shows the highest nucleotide identity (98.79%) and amino acid identity (98.02%) to the MRV3 strain IND/MZ/3013789/reo derived from Indian pigs in 2017. The σ1 protein of the virus contains the amino acid residues linked to the sialic acid-binding site as well as neurotropism (198–204 NLAIRLP, 249I, 340D, 419E), suggesting a potential for broader mammalian infectivity. This study provides a basis for investigating the epidemiology, genetic evolution, and zoonotic spillover potential of MRV in mammals.